The use of sedative drugs in intensive care is ubiquitous. Every year, more than 3 million patients worldwide, 50,000 patients in Australia and New Zealand [1, 2] and nearly 800,000 in the United States receive mechanical ventilation and sedation with an in-hospital mortality (2005) of 34.5 . The estimated US national cost per annum reached nearly US27 billion in 2005 . In Ontario, in 1992, the number of mechanically ventilated patients was 221/100,000 population with the estimated number of ventilated patients across Canada likely to exceed 75,000 per annum . The number of ventilated patients per 100,000 population is likely to be similar in Europe. Projections suggests that this number is expected to rise by 31 over the next decade . Almost all ventilated patients receive sedative agents in one form or another . Sedation is given to promote tolerance of endotracheal intubation and associated life-sustaining interventions, including mechanical ventilation, and to relieve anxiety and reduce distress . Thus, sedation is considered vital to patient comfort and safety.
|Title of host publication||Annual Update in Intensive Care and Emergency Medicine 2014|
|Place of Publication||Switzerland|
|Pages||651 - 661|
|Number of pages||11|
|Publication status||Published - 2014|
Shehabi, Y., Bellomo, R., & Kadiman, S. (2014). Early goal-directed sedation in mechanically ventilated patients. In J-L. Vincent (Ed.), Annual Update in Intensive Care and Emergency Medicine 2014 (pp. 651 - 661). Springer. https://doi.org/10.1007/978-3-319-03746-2_48