Early general movements and brain magnetic resonance imaging at term-equivalent age in infants born < 30 weeks' gestation

Joy E. Olsen, Nisha C. Brown, Abbey L. Eeles, Christa Einspieler, Katherine J. Lee, Deanne K. Thompson, Peter J. Anderson, Jeanie L Y Cheong, Lex W. Doyle, Alicia J. Spittle

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background: Neurodevelopmental assessments and brain magnetic resonance imaging (MRI) at term-equivalent age (TEA) predict developmental outcomes in preterm infants. However, the relationship between neurodevelopment prior to term and cerebral structure is currently unknown. Aims: To examine the relationships between General Movements (GMs) assessed from birth to TEA and brain MRI at TEA in infants born < 30 weeks' gestation. Study design: Prospective cohort study. GMs (categorised as ‘normal’ or ‘abnormal’) were recorded weekly from birth to 32 weeks, and at 34 and 36 weeks' postmenstrual age. At TEA, GMs were assessed concurrently with brain MRI (using a validated scoring system). Subjects: 149 infants born < 30 weeks' gestation were recruited from a tertiary hospital. Results: 103 infants had MRI at TEA and GMs recorded. Abnormal GMs prior to term were associated with cortical grey matter abnormality (p < 0.03), deep grey matter abnormality (p = 0.02) and increased interhemispheric distance (p < 0.02). Abnormal GMs at TEA (n = 55/90) were associated with more global brain abnormality (p < 0.01) and cortical grey matter abnormality (p = 0.01), and decreased transcerebellar diameter (p = 0.04) on concurrent brain MRI. Conclusions: Abnormal GMs both prior to term and at TEA were associated with more marked brain abnormality, and smaller brains at TEA. Abnormal GMs are an early marker of brain abnormalities in very preterm infants.

Original languageEnglish
Pages (from-to)63-68
Number of pages6
JournalEarly Human Development
Volume101
DOIs
Publication statusPublished - Oct 2016
Externally publishedYes

Keywords

  • General movements
  • Magnetic resonance imaging
  • Neurodevelopmental assessment
  • Preterm infant

Cite this

Olsen, J. E., Brown, N. C., Eeles, A. L., Einspieler, C., Lee, K. J., Thompson, D. K., ... Spittle, A. J. (2016). Early general movements and brain magnetic resonance imaging at term-equivalent age in infants born < 30 weeks' gestation. Early Human Development, 101, 63-68. https://doi.org/10.1016/j.earlhumdev.2016.06.009
Olsen, Joy E. ; Brown, Nisha C. ; Eeles, Abbey L. ; Einspieler, Christa ; Lee, Katherine J. ; Thompson, Deanne K. ; Anderson, Peter J. ; Cheong, Jeanie L Y ; Doyle, Lex W. ; Spittle, Alicia J. / Early general movements and brain magnetic resonance imaging at term-equivalent age in infants born < 30 weeks' gestation. In: Early Human Development. 2016 ; Vol. 101. pp. 63-68.
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title = "Early general movements and brain magnetic resonance imaging at term-equivalent age in infants born < 30 weeks' gestation",
abstract = "Background: Neurodevelopmental assessments and brain magnetic resonance imaging (MRI) at term-equivalent age (TEA) predict developmental outcomes in preterm infants. However, the relationship between neurodevelopment prior to term and cerebral structure is currently unknown. Aims: To examine the relationships between General Movements (GMs) assessed from birth to TEA and brain MRI at TEA in infants born < 30 weeks' gestation. Study design: Prospective cohort study. GMs (categorised as ‘normal’ or ‘abnormal’) were recorded weekly from birth to 32 weeks, and at 34 and 36 weeks' postmenstrual age. At TEA, GMs were assessed concurrently with brain MRI (using a validated scoring system). Subjects: 149 infants born < 30 weeks' gestation were recruited from a tertiary hospital. Results: 103 infants had MRI at TEA and GMs recorded. Abnormal GMs prior to term were associated with cortical grey matter abnormality (p < 0.03), deep grey matter abnormality (p = 0.02) and increased interhemispheric distance (p < 0.02). Abnormal GMs at TEA (n = 55/90) were associated with more global brain abnormality (p < 0.01) and cortical grey matter abnormality (p = 0.01), and decreased transcerebellar diameter (p = 0.04) on concurrent brain MRI. Conclusions: Abnormal GMs both prior to term and at TEA were associated with more marked brain abnormality, and smaller brains at TEA. Abnormal GMs are an early marker of brain abnormalities in very preterm infants.",
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Olsen, JE, Brown, NC, Eeles, AL, Einspieler, C, Lee, KJ, Thompson, DK, Anderson, PJ, Cheong, JLY, Doyle, LW & Spittle, AJ 2016, 'Early general movements and brain magnetic resonance imaging at term-equivalent age in infants born < 30 weeks' gestation' Early Human Development, vol. 101, pp. 63-68. https://doi.org/10.1016/j.earlhumdev.2016.06.009

Early general movements and brain magnetic resonance imaging at term-equivalent age in infants born < 30 weeks' gestation. / Olsen, Joy E.; Brown, Nisha C.; Eeles, Abbey L.; Einspieler, Christa; Lee, Katherine J.; Thompson, Deanne K.; Anderson, Peter J.; Cheong, Jeanie L Y; Doyle, Lex W.; Spittle, Alicia J.

In: Early Human Development, Vol. 101, 10.2016, p. 63-68.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Early general movements and brain magnetic resonance imaging at term-equivalent age in infants born < 30 weeks' gestation

AU - Olsen, Joy E.

AU - Brown, Nisha C.

AU - Eeles, Abbey L.

AU - Einspieler, Christa

AU - Lee, Katherine J.

AU - Thompson, Deanne K.

AU - Anderson, Peter J.

AU - Cheong, Jeanie L Y

AU - Doyle, Lex W.

AU - Spittle, Alicia J.

PY - 2016/10

Y1 - 2016/10

N2 - Background: Neurodevelopmental assessments and brain magnetic resonance imaging (MRI) at term-equivalent age (TEA) predict developmental outcomes in preterm infants. However, the relationship between neurodevelopment prior to term and cerebral structure is currently unknown. Aims: To examine the relationships between General Movements (GMs) assessed from birth to TEA and brain MRI at TEA in infants born < 30 weeks' gestation. Study design: Prospective cohort study. GMs (categorised as ‘normal’ or ‘abnormal’) were recorded weekly from birth to 32 weeks, and at 34 and 36 weeks' postmenstrual age. At TEA, GMs were assessed concurrently with brain MRI (using a validated scoring system). Subjects: 149 infants born < 30 weeks' gestation were recruited from a tertiary hospital. Results: 103 infants had MRI at TEA and GMs recorded. Abnormal GMs prior to term were associated with cortical grey matter abnormality (p < 0.03), deep grey matter abnormality (p = 0.02) and increased interhemispheric distance (p < 0.02). Abnormal GMs at TEA (n = 55/90) were associated with more global brain abnormality (p < 0.01) and cortical grey matter abnormality (p = 0.01), and decreased transcerebellar diameter (p = 0.04) on concurrent brain MRI. Conclusions: Abnormal GMs both prior to term and at TEA were associated with more marked brain abnormality, and smaller brains at TEA. Abnormal GMs are an early marker of brain abnormalities in very preterm infants.

AB - Background: Neurodevelopmental assessments and brain magnetic resonance imaging (MRI) at term-equivalent age (TEA) predict developmental outcomes in preterm infants. However, the relationship between neurodevelopment prior to term and cerebral structure is currently unknown. Aims: To examine the relationships between General Movements (GMs) assessed from birth to TEA and brain MRI at TEA in infants born < 30 weeks' gestation. Study design: Prospective cohort study. GMs (categorised as ‘normal’ or ‘abnormal’) were recorded weekly from birth to 32 weeks, and at 34 and 36 weeks' postmenstrual age. At TEA, GMs were assessed concurrently with brain MRI (using a validated scoring system). Subjects: 149 infants born < 30 weeks' gestation were recruited from a tertiary hospital. Results: 103 infants had MRI at TEA and GMs recorded. Abnormal GMs prior to term were associated with cortical grey matter abnormality (p < 0.03), deep grey matter abnormality (p = 0.02) and increased interhemispheric distance (p < 0.02). Abnormal GMs at TEA (n = 55/90) were associated with more global brain abnormality (p < 0.01) and cortical grey matter abnormality (p = 0.01), and decreased transcerebellar diameter (p = 0.04) on concurrent brain MRI. Conclusions: Abnormal GMs both prior to term and at TEA were associated with more marked brain abnormality, and smaller brains at TEA. Abnormal GMs are an early marker of brain abnormalities in very preterm infants.

KW - General movements

KW - Magnetic resonance imaging

KW - Neurodevelopmental assessment

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