TY - JOUR
T1 - Early events of HIV-1 infection: Can signaling be the next therapeutic target?
AU - Jones, Kate L
AU - Smyth, Redmond P
AU - Pereira, Candida da Fonseca
AU - Cameron, Paul U
AU - Lewin, Sharon R
AU - Jaworowski, Anthony
AU - Mak, Johnson
PY - 2011
Y1 - 2011
N2 - Intracellular signaling events are signposts of biological processes, which govern the direction and action of biological activities. Through millions of years of evolution, pathogens, such as viruses, have evolved to hijack host cell machinery to infect their targets and are therefore dependent on host cell signaling for replication. This review will detail our current understanding of the signaling events that are important for the early steps of HIV-1 replication. More specifically, the therapeutic potential of signaling events associated with chemokine coreceptors, virus entry, viral synapses, and post-entry processes will be discussed. We argue that these pathways may represent novel targets for antiviral therapy.
AB - Intracellular signaling events are signposts of biological processes, which govern the direction and action of biological activities. Through millions of years of evolution, pathogens, such as viruses, have evolved to hijack host cell machinery to infect their targets and are therefore dependent on host cell signaling for replication. This review will detail our current understanding of the signaling events that are important for the early steps of HIV-1 replication. More specifically, the therapeutic potential of signaling events associated with chemokine coreceptors, virus entry, viral synapses, and post-entry processes will be discussed. We argue that these pathways may represent novel targets for antiviral therapy.
UR - http://www.springerlink.com/content/p781045051791572/fulltext.pdf
U2 - 10.1007/s11481-011-9268-5
DO - 10.1007/s11481-011-9268-5
M3 - Article
SN - 1557-1890
VL - 6
SP - 269
EP - 283
JO - Journal of Neuroimmune Pharmacology
JF - Journal of Neuroimmune Pharmacology
IS - 2
ER -