Early events of HIV-1 infection: Can signaling be the next therapeutic target?

Kate L Jones, Redmond P Smyth, Candida da Fonseca Pereira, Paul U Cameron, Sharon R Lewin, Anthony Jaworowski, Johnson Mak

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)


Intracellular signaling events are signposts of biological processes, which govern the direction and action of biological activities. Through millions of years of evolution, pathogens, such as viruses, have evolved to hijack host cell machinery to infect their targets and are therefore dependent on host cell signaling for replication. This review will detail our current understanding of the signaling events that are important for the early steps of HIV-1 replication. More specifically, the therapeutic potential of signaling events associated with chemokine coreceptors, virus entry, viral synapses, and post-entry processes will be discussed. We argue that these pathways may represent novel targets for antiviral therapy.
Original languageEnglish
Pages (from-to)269 - 283
Number of pages15
JournalJournal of Neuroimmune Pharmacology
Issue number2
Publication statusPublished - 2011

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