Early detection of memory impairment in Alzheimer's disease: A neurocognitive perspective on assessment

Georgina Johanna Camplin, Gregory Raymond Savage

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Abstract

We propose that the earliest neuropsychological detection of Alzheimer s disease (AD) can be informed by current views about the neuropathogenesis of AD and cognitive models of memory and its neurobiological substrates. The primary impairment in early AD is encoding/consolidation, resulting from medial temporal lobe (MTL) pathology. On theoretical and empirical grounds, paired associate learning (PAL) appears to be the ideal paradigm for detecting MTL dysfunction in early AD. It has not been embraced as a test of choice, however, and this critical review discusses why the paradigm may have not fulfilled its potential. We suggest that a new PAL variant, associate-recognition , may prove to be clinically efficacious.
Original languageEnglish
Pages (from-to)193 - 202
Number of pages10
JournalNeuropsychology Review
Volume17
Issue number3
Publication statusPublished - 2007

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