Earlier intervention in type 2 diabetes: The case for achieving early and sustained glycaemic control

Clifford J. Bailey, Stefano Del Prato, D. Eddy, Bernard Zinman, George Albetti, P. Pablo Aschner, Lawrence Blonde, Anne Marie Felton, Barry Goldstein, Ramon Gomis, Edward Horton, James LaSalle J., Hong Kyu Lee, Lawrence Leiter, Stephan Matthaei, Marg McGill, Neil Munro, Richard Nesto, Paul Zimmet

Research output: Contribution to journalReview ArticleResearchpeer-review

49 Citations (Scopus)


In type 2 diabetes, the onset and progression of complications is significantly delayed by improving glycaemic control. However, the proportion of patients reaching and sustaining guideline recommendations for glycaemic targets remains unacceptably low. Recent clinical trials and predictive physiologically based mathematical simulations (Archimedes model) indicate that benefits can be enhanced with earlier intervention and timely achievement of glycaemic targets. This article reviews the evidence for early intervention, showing that intensive approaches, including earlier introduction of combination therapy, allow more patients to achieve glycaemic targets and hence reduce complications and delay disease progression.

Original languageEnglish
Pages (from-to)1309-1316
Number of pages8
JournalInternational Journal of Clinical Practice
Issue number11
Publication statusPublished - Nov 2005
Externally publishedYes


  • Archimedes model
  • Combination therapy
  • Early intervention
  • Glycaemic control
  • Type 2 diabetes

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