Earlier intervention in type 2 diabetes: The case for achieving early and sustained glycaemic control

Clifford J. Bailey; Stefano Del Prato; D. Eddy; Bernard Zinman; George Albetti; P. Pablo Aschner; Lawrence Blonde; Anne Marie Felton; Barry Goldstein; Ramon Gomis; Edward Horton; James LaSalle J.; Hong Kyu Lee; Lawrence Leiter; Stephan Matthaei; Marg McGill; Neil Munro; Richard Nesto; Paul Zimmet

doi:10.1111/j.1742-1241.2005.00675.x

Earlier intervention in type 2 diabetes: The case for achieving early and sustained glycaemic control

Clifford J. Bailey, Stefano Del Prato, D. Eddy, Bernard Zinman, George Albetti, P. Pablo Aschner, Lawrence Blonde, Anne Marie Felton, Barry Goldstein, Ramon Gomis, Edward Horton, James LaSalle J., Hong Kyu Lee, Lawrence Leiter, Stephan Matthaei, Marg McGill, Neil Munro, Richard Nesto, Paul Zimmet

Research output: Contribution to journal › Review Article › Research › peer-review

49 Citations (Scopus)

Abstract

In type 2 diabetes, the onset and progression of complications is significantly delayed by improving glycaemic control. However, the proportion of patients reaching and sustaining guideline recommendations for glycaemic targets remains unacceptably low. Recent clinical trials and predictive physiologically based mathematical simulations (Archimedes model) indicate that benefits can be enhanced with earlier intervention and timely achievement of glycaemic targets. This article reviews the evidence for early intervention, showing that intensive approaches, including earlier introduction of combination therapy, allow more patients to achieve glycaemic targets and hence reduce complications and delay disease progression.

Original language	English
Pages (from-to)	1309-1316
Number of pages	8
Journal	International Journal of Clinical Practice
Volume	59
Issue number	11
DOIs	https://doi.org/10.1111/j.1742-1241.2005.00675.x
Publication status	Published - Nov 2005
Externally published	Yes

Keywords

Archimedes model
Combination therapy
Early intervention
Glycaemic control
Type 2 diabetes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1742-1241.2005.00675.x

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Bailey, C. J., Del Prato, S., Eddy, D., Zinman, B., Albetti, G., Aschner, P. P., Blonde, L., Felton, A. M., Goldstein, B., Gomis, R., Horton, E., LaSalle J., J., Lee, H. K., Leiter, L., Matthaei, S., McGill, M., Munro, N., Nesto, R., & Zimmet, P. (2005). Earlier intervention in type 2 diabetes: The case for achieving early and sustained glycaemic control. International Journal of Clinical Practice, 59(11), 1309-1316. https://doi.org/10.1111/j.1742-1241.2005.00675.x

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abstract = "In type 2 diabetes, the onset and progression of complications is significantly delayed by improving glycaemic control. However, the proportion of patients reaching and sustaining guideline recommendations for glycaemic targets remains unacceptably low. Recent clinical trials and predictive physiologically based mathematical simulations (Archimedes model) indicate that benefits can be enhanced with earlier intervention and timely achievement of glycaemic targets. This article reviews the evidence for early intervention, showing that intensive approaches, including earlier introduction of combination therapy, allow more patients to achieve glycaemic targets and hence reduce complications and delay disease progression.",

keywords = "Archimedes model, Combination therapy, Early intervention, Glycaemic control, Type 2 diabetes",

author = "Bailey, {Clifford J.} and {Del Prato}, Stefano and D. Eddy and Bernard Zinman and George Albetti and Aschner, {P. Pablo} and Lawrence Blonde and Felton, {Anne Marie} and Barry Goldstein and Ramon Gomis and Edward Horton and {LaSalle J.}, James and Lee, {Hong Kyu} and Lawrence Leiter and Stephan Matthaei and Marg McGill and Neil Munro and Richard Nesto and Paul Zimmet",

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doi = "10.1111/j.1742-1241.2005.00675.x",

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Bailey, CJ, Del Prato, S, Eddy, D, Zinman, B, Albetti, G, Aschner, PP, Blonde, L, Felton, AM, Goldstein, B, Gomis, R, Horton, E, LaSalle J., J, Lee, HK, Leiter, L, Matthaei, S, McGill, M, Munro, N, Nesto, R & Zimmet, P 2005, 'Earlier intervention in type 2 diabetes: The case for achieving early and sustained glycaemic control', International Journal of Clinical Practice, vol. 59, no. 11, pp. 1309-1316. https://doi.org/10.1111/j.1742-1241.2005.00675.x

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T2 - The case for achieving early and sustained glycaemic control

AU - Bailey, Clifford J.

AU - Del Prato, Stefano

AU - Eddy, D.

AU - Zinman, Bernard

AU - Albetti, George

AU - Aschner, P. Pablo

AU - Blonde, Lawrence

AU - Felton, Anne Marie

AU - Goldstein, Barry

AU - Gomis, Ramon

AU - Horton, Edward

AU - LaSalle J., James

AU - Lee, Hong Kyu

AU - Leiter, Lawrence

AU - Matthaei, Stephan

AU - McGill, Marg

AU - Munro, Neil

AU - Nesto, Richard

AU - Zimmet, Paul

PY - 2005/11

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N2 - In type 2 diabetes, the onset and progression of complications is significantly delayed by improving glycaemic control. However, the proportion of patients reaching and sustaining guideline recommendations for glycaemic targets remains unacceptably low. Recent clinical trials and predictive physiologically based mathematical simulations (Archimedes model) indicate that benefits can be enhanced with earlier intervention and timely achievement of glycaemic targets. This article reviews the evidence for early intervention, showing that intensive approaches, including earlier introduction of combination therapy, allow more patients to achieve glycaemic targets and hence reduce complications and delay disease progression.

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KW - Archimedes model

KW - Combination therapy

KW - Early intervention

KW - Glycaemic control

KW - Type 2 diabetes

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SN - 1368-5031

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Earlier intervention in type 2 diabetes: The case for achieving early and sustained glycaemic control

Abstract

Keywords

UN SDGs

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