Dysregulation of the basal RNA polymerase transcription apparatus in cancer

Megan Bywater, Richard Bruce Pearson, Grant A McArthur, Ross Duncan Hannan

Research output: Contribution to journalArticleResearchpeer-review

126 Citations (Scopus)

Abstract

Mutations that directly affect transcription by RNA polymerases rank among the most central mediators of malignant transformation, but the frequency of new anticancer drugs that selectively target defective transcription apparatus entering the clinic has been limited. This is because targeting the large protein-protein and protein-DNA interfaces that control both generic and selective aspects of RNA polymerase transcription has proved extremely difficult. However, recent technological advances have led to a quantum leap in our comprehension of the structure and function of the core RNA polymerase components, how they are dysregulated in a broad range of cancers and how they may be targeted for transcription therapy .
Original languageEnglish
Pages (from-to)299 - 314
Number of pages16
JournalNature Reviews Cancer
Volume13
Issue number5
DOIs
Publication statusPublished - 2013

Cite this