Dyslipidaemia as a risk factor for erectile dysfunction in type 2 diabetes mellitus patients

Abul Kalam Azad, Sumudu Setunge, Shahjada Selim, Shahabul Huda Chowdhury, Mohammad Ferdousur Rahaman, Md Abdul Jalil Chowdhury, Barbora de Courten, Dragan Ilic, Md Nazmul Karim

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background: Despite epidemiological studies worldwide have documented erectile dysfunction (ED) as a major complication of type 2 diabetes Mellitus (T2DM) in men, only limited research reported on determinants of ED in this population. The study aimed at examining the association of ED with dyslipidaemia in T2DM patients. Methods: The study enrolled 813 consecutive eligible adult male T2DM patients attending the endocrinology departments of a tertiary teaching hospital in Bangladesh. Sexual function was assessed using modified International Index of Erectile Function (IIEF) in face-to-face interview and collected along with sociodemographic information. Diabetes and lipid profile and treatment history were collected from patient's treatment records. Association of ED with dyslipidaemia was assessed using multivariable logistic regression adjusting for potential confounders. Result: Prevalence of ED among the T2DM patients was very high (72.7%), of which around half had moderated-to-severe ED. Odds of having dyslipidaemia among T2DM patients with ED is 2.3 times higher than those without. The odds increased by approximately 3 fold for an abnormal High Density Lipoprotein level and by 2.7 fold for abnormal Low Density Lipoprotein. Conclusion: Dyslipidaemia was associated with increased ED risk among T2DM. Abnormal lipoprotein level particularly were found to pose greater risk.

Original languageEnglish
Pages (from-to)748-753
Number of pages6
JournalDiabetes and Metabolic Syndrome: Clinical Research and Reviews
Volume13
Issue number1
DOIs
Publication statusPublished - 1 Jan 2019

Keywords

  • Diabetic complication
  • Dyslipidaemia
  • Erectile dysfunction
  • Lipoprotein
  • Sexual function
  • Type 2 diabetes mellitus

Cite this

Azad, Abul Kalam ; Setunge, Sumudu ; Selim, Shahjada ; Chowdhury, Shahabul Huda ; Rahaman, Mohammad Ferdousur ; Chowdhury, Md Abdul Jalil ; de Courten, Barbora ; Ilic, Dragan ; Karim, Md Nazmul. / Dyslipidaemia as a risk factor for erectile dysfunction in type 2 diabetes mellitus patients. In: Diabetes and Metabolic Syndrome: Clinical Research and Reviews. 2019 ; Vol. 13, No. 1. pp. 748-753.
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abstract = "Background: Despite epidemiological studies worldwide have documented erectile dysfunction (ED) as a major complication of type 2 diabetes Mellitus (T2DM) in men, only limited research reported on determinants of ED in this population. The study aimed at examining the association of ED with dyslipidaemia in T2DM patients. Methods: The study enrolled 813 consecutive eligible adult male T2DM patients attending the endocrinology departments of a tertiary teaching hospital in Bangladesh. Sexual function was assessed using modified International Index of Erectile Function (IIEF) in face-to-face interview and collected along with sociodemographic information. Diabetes and lipid profile and treatment history were collected from patient's treatment records. Association of ED with dyslipidaemia was assessed using multivariable logistic regression adjusting for potential confounders. Result: Prevalence of ED among the T2DM patients was very high (72.7{\%}), of which around half had moderated-to-severe ED. Odds of having dyslipidaemia among T2DM patients with ED is 2.3 times higher than those without. The odds increased by approximately 3 fold for an abnormal High Density Lipoprotein level and by 2.7 fold for abnormal Low Density Lipoprotein. Conclusion: Dyslipidaemia was associated with increased ED risk among T2DM. Abnormal lipoprotein level particularly were found to pose greater risk.",
keywords = "Diabetic complication, Dyslipidaemia, Erectile dysfunction, Lipoprotein, Sexual function, Type 2 diabetes mellitus",
author = "Azad, {Abul Kalam} and Sumudu Setunge and Shahjada Selim and Chowdhury, {Shahabul Huda} and Rahaman, {Mohammad Ferdousur} and Chowdhury, {Md Abdul Jalil} and {de Courten}, Barbora and Dragan Ilic and Karim, {Md Nazmul}",
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Dyslipidaemia as a risk factor for erectile dysfunction in type 2 diabetes mellitus patients. / Azad, Abul Kalam; Setunge, Sumudu; Selim, Shahjada; Chowdhury, Shahabul Huda; Rahaman, Mohammad Ferdousur; Chowdhury, Md Abdul Jalil; de Courten, Barbora; Ilic, Dragan; Karim, Md Nazmul.

In: Diabetes and Metabolic Syndrome: Clinical Research and Reviews, Vol. 13, No. 1, 01.01.2019, p. 748-753.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Dyslipidaemia as a risk factor for erectile dysfunction in type 2 diabetes mellitus patients

AU - Azad, Abul Kalam

AU - Setunge, Sumudu

AU - Selim, Shahjada

AU - Chowdhury, Shahabul Huda

AU - Rahaman, Mohammad Ferdousur

AU - Chowdhury, Md Abdul Jalil

AU - de Courten, Barbora

AU - Ilic, Dragan

AU - Karim, Md Nazmul

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Despite epidemiological studies worldwide have documented erectile dysfunction (ED) as a major complication of type 2 diabetes Mellitus (T2DM) in men, only limited research reported on determinants of ED in this population. The study aimed at examining the association of ED with dyslipidaemia in T2DM patients. Methods: The study enrolled 813 consecutive eligible adult male T2DM patients attending the endocrinology departments of a tertiary teaching hospital in Bangladesh. Sexual function was assessed using modified International Index of Erectile Function (IIEF) in face-to-face interview and collected along with sociodemographic information. Diabetes and lipid profile and treatment history were collected from patient's treatment records. Association of ED with dyslipidaemia was assessed using multivariable logistic regression adjusting for potential confounders. Result: Prevalence of ED among the T2DM patients was very high (72.7%), of which around half had moderated-to-severe ED. Odds of having dyslipidaemia among T2DM patients with ED is 2.3 times higher than those without. The odds increased by approximately 3 fold for an abnormal High Density Lipoprotein level and by 2.7 fold for abnormal Low Density Lipoprotein. Conclusion: Dyslipidaemia was associated with increased ED risk among T2DM. Abnormal lipoprotein level particularly were found to pose greater risk.

AB - Background: Despite epidemiological studies worldwide have documented erectile dysfunction (ED) as a major complication of type 2 diabetes Mellitus (T2DM) in men, only limited research reported on determinants of ED in this population. The study aimed at examining the association of ED with dyslipidaemia in T2DM patients. Methods: The study enrolled 813 consecutive eligible adult male T2DM patients attending the endocrinology departments of a tertiary teaching hospital in Bangladesh. Sexual function was assessed using modified International Index of Erectile Function (IIEF) in face-to-face interview and collected along with sociodemographic information. Diabetes and lipid profile and treatment history were collected from patient's treatment records. Association of ED with dyslipidaemia was assessed using multivariable logistic regression adjusting for potential confounders. Result: Prevalence of ED among the T2DM patients was very high (72.7%), of which around half had moderated-to-severe ED. Odds of having dyslipidaemia among T2DM patients with ED is 2.3 times higher than those without. The odds increased by approximately 3 fold for an abnormal High Density Lipoprotein level and by 2.7 fold for abnormal Low Density Lipoprotein. Conclusion: Dyslipidaemia was associated with increased ED risk among T2DM. Abnormal lipoprotein level particularly were found to pose greater risk.

KW - Diabetic complication

KW - Dyslipidaemia

KW - Erectile dysfunction

KW - Lipoprotein

KW - Sexual function

KW - Type 2 diabetes mellitus

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DO - 10.1016/j.dsx.2018.11.052

M3 - Article

VL - 13

SP - 748

EP - 753

JO - Diabetes and Metabolic Syndrome: Clinical Research and Reviews

JF - Diabetes and Metabolic Syndrome: Clinical Research and Reviews

SN - 1871-4021

IS - 1

ER -