Dysfunctional uterine bleeding in adolescence

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This paper assesses the basic steps of management and treatment of dysfunctional uterine bleeding (DUB) - the irregular bleeding arising from anovulation. After menarche, the hypothalamic-pituitary-ovarian axis can take several years to mature resulting in anovulatory and therefore irregular cycles. During an anovulatory cycle, the corpus luteum fails to form, causing failure of normal cyclical progesterone secretion. This results in continuous unopposed production of estradiol, stimulating overgrowth of the endometrium. Without progesterone, the endometrium grows thicker and thicker eventually outgrowing its blood supply, leading to necrosis. The end result is very heavy bleeding.

Original languageEnglish
Pages (from-to)211-212
Number of pages2
JournalWomen's Health Medicine
Issue number5
Publication statusPublished - 1 Sept 2006


  • dysfunctional
  • estradiol
  • progesterone
  • uterine bleeding

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