Dynamics of population activity in rat sensory cortex: Network correlations predict anatomical arrangement and information content

Mohammad Mahdi Sabri, Mehdi Adibi, Ehsan Arabzadeh

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Abstract

To study the spatiotemporal dynamics of neural activity in a cortical population, we implanted a 10 × 10 microelectrode array in the vibrissalcortex of urethane-anesthetized rats. We recorded spontaneous neuronal activity as well as activity evoked in response to sustained and briefsensory stimulation. To quantify the temporal dynamics of activity, we computed the probability distribution function (PDF) of spiking on one electrode given the observation of a spike on another. The spike-triggered PDFs quantified the strength, temporal delay, and temporal precision of correlated activity across electrodes. Nearby cells showed higher levels of correlation at short delays, whereas distant cells showed lower levels of correlation, which tended to occur at longer delays. We found that functional space built based on the strength of pairwise correlations predicted the anatomical arrangement of electrodes. Moreover, the correlation profile of electrode pairs during spontaneous activity predicted the "signal" and "noise" correlations during sensory stimulation. Finally, mutual information analyses revealed that neurons with stronger correlations to thenetwork during spontaneous activity, conveyed higher information about the sensory stimuli in their evoked response. Given the 400-μm-distance between adjacent electrodes, our functional quantifications unravel the spatiotemporal dynamics of activity among nearby and distant cortical columns.

Original languageEnglish
Article number49
Number of pages11
JournalFrontiers in Neural Circuits
Volume10
Issue numberJUL2016
DOIs
Publication statusPublished - 6 Jul 2016
Externally publishedYes

Keywords

  • Barrel cortex
  • Noise correlation
  • Sensory coding
  • Signal correlation
  • Vibrissal

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