Dynamic synchrotron imaging of diabetic rat coronary microcirculation in vivo

Mathew J Jenkins, Amanda J Edgley, Takashi Sonobe, Keiji Umetani, Daryl Schwenke, Yutaka Fujii, Russell D Brown, Darren J Kelly, Mikiyasu Shirai, James T Pearson

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Abstract

In diabetes, long-term micro- and macrovascular damage often underlies the functional decline in the cardiovascular system. However, it remains unclear whether early-stage diabetes is associated with in vivo functional impairment in the coronary microvasculature. Synchrotron imaging allows us to detect and quantify regional differences in resistance microvessel caliber in vivo, even under conditions of high heart rate. METHODS AND RESULTS: Synchrotron cine-angiograms of the coronary vasculature were recorded using anesthetized Sprague-Dawley rats 3 weeks after treatment with vehicle or streptozotocin (diabetic). In the early diabetic state, in the presence of nitric oxide and prostacyclin , vessel diameters were smaller (P
Original languageEnglish
Pages (from-to)370 - 377
Number of pages8
JournalArteriosclerosis, Thrombosis and Vascular Biology
Volume32
Issue number2
DOIs
Publication statusPublished - 2012

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