Dynamic mRNP Remodeling in Response to Internal and External Stimuli

Kathi Zarnack, Sureshkumar Balasubramanian, Michael P. Gantier, Vladislav Kunetsky, Michael Kracht, M. Lienhard Schmitz, Katja Sträßer

Research output: Contribution to journalReview ArticleOtherpeer-review

12 Citations (Scopus)

Abstract

Signal transduction and the regulation of gene expression are fundamental processes in every cell. RNA-binding proteins (RBPs) play a key role in the post-transcriptional modulation of gene expression in response to both internal and external stimuli. However, how signaling pathways regulate the assembly of RBPs with mRNAs remains largely unknown. Here, we summarize observations showing that the formation and composition of messenger ribonucleoprotein particles (mRNPs) is dynamically remodeled in space and time by specific signaling cascades and the resulting post-translational modifications. The integration of signaling events with gene expression is key to the rapid adaptation of cells to environmental changes and stress. Only a combined approach analyzing the signal transduction pathways and the changes in post-transcriptional gene expression they cause will unravel the mechanisms coordinating these important cellular processes.

Original languageEnglish
Article number1310
Number of pages32
JournalBiomolecules
Volume10
Issue number9
DOIs
Publication statusPublished - 11 Sept 2020

Keywords

  • extracellular stimuli
  • intracellular stimuli
  • messenger ribonucleoprotein particles (mRNPs)
  • post-transcriptional gene regulation
  • RNA-binding proteins (RBPs)
  • signal transduction
  • stress

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