Dynamic evaluation and control of blood clotting using a microfluidic platform for high-throughput diagnostics

Miguel E. Combariza, Xinghuo Yu, Warwick Nesbitt, Francisco Tovar-Lopez, Dominik G. Rabus, Arnan Mitchell

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

Abstract

Microfluidic technology has the potential to revolutionise blood-clotting diagnostics by incorporating key physiological blood flow conditions like shear rate. In this paper we present a customised dynamic microfluidic system, which evaluates the blood clotting response to multiple conditions of shear rate on a single microchannel. The system can achieve high-throughput testing through use of an advanced fluid control system, which provides with rapid and precise regulation of the blood flow conditions in the platform. We present experimental results that demonstrate the potential of this platform to develop into a high-throughput, low-cost, blood-clotting diagnostics device.

Original languageEnglish
Title of host publicationMicro+Nano Materials, Devices, and Systems
EditorsStefano Palomba, Benjamin J. Eggleton
Place of PublicationBellingham WA USA
PublisherSPIE
Number of pages10
ISBN (Electronic)9781628418903
DOIs
Publication statusPublished - 1 Jan 2015
EventSPIE Micro+Nano Materials, Devices, and Applications Symposium 2015 - The University of Sydney, Sydney, Australia
Duration: 6 Dec 20159 Dec 2015
http://spie.org/conferences-and-exhibitions/micronano-materials-devices-and-applications?SSO=1

Publication series

NameProceedings of SPIE
PublisherThe International Society for Optical Engineering
Volume9668
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X

Conference

ConferenceSPIE Micro+Nano Materials, Devices, and Applications Symposium 2015
CountryAustralia
CitySydney
Period6/12/159/12/15
Internet address

Keywords

  • automation
  • blood clotting
  • diagnostics
  • Dynamic modelling
  • high-throughput
  • microuidics
  • ow control

Cite this

Combariza, M. E., Yu, X., Nesbitt, W., Tovar-Lopez, F., Rabus, D. G., & Mitchell, A. (2015). Dynamic evaluation and control of blood clotting using a microfluidic platform for high-throughput diagnostics. In S. Palomba, & B. J. Eggleton (Eds.), Micro+Nano Materials, Devices, and Systems [96681U] (Proceedings of SPIE; Vol. 9668). Bellingham WA USA: SPIE. https://doi.org/10.1117/12.2202367
Combariza, Miguel E. ; Yu, Xinghuo ; Nesbitt, Warwick ; Tovar-Lopez, Francisco ; Rabus, Dominik G. ; Mitchell, Arnan. / Dynamic evaluation and control of blood clotting using a microfluidic platform for high-throughput diagnostics. Micro+Nano Materials, Devices, and Systems. editor / Stefano Palomba ; Benjamin J. Eggleton. Bellingham WA USA : SPIE, 2015. (Proceedings of SPIE).
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abstract = "Microfluidic technology has the potential to revolutionise blood-clotting diagnostics by incorporating key physiological blood flow conditions like shear rate. In this paper we present a customised dynamic microfluidic system, which evaluates the blood clotting response to multiple conditions of shear rate on a single microchannel. The system can achieve high-throughput testing through use of an advanced fluid control system, which provides with rapid and precise regulation of the blood flow conditions in the platform. We present experimental results that demonstrate the potential of this platform to develop into a high-throughput, low-cost, blood-clotting diagnostics device.",
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Combariza, ME, Yu, X, Nesbitt, W, Tovar-Lopez, F, Rabus, DG & Mitchell, A 2015, Dynamic evaluation and control of blood clotting using a microfluidic platform for high-throughput diagnostics. in S Palomba & BJ Eggleton (eds), Micro+Nano Materials, Devices, and Systems., 96681U, Proceedings of SPIE, vol. 9668, SPIE, Bellingham WA USA, SPIE Micro+Nano Materials, Devices, and Applications Symposium 2015, Sydney, Australia, 6/12/15. https://doi.org/10.1117/12.2202367

Dynamic evaluation and control of blood clotting using a microfluidic platform for high-throughput diagnostics. / Combariza, Miguel E.; Yu, Xinghuo; Nesbitt, Warwick; Tovar-Lopez, Francisco; Rabus, Dominik G.; Mitchell, Arnan.

Micro+Nano Materials, Devices, and Systems. ed. / Stefano Palomba; Benjamin J. Eggleton. Bellingham WA USA : SPIE, 2015. 96681U (Proceedings of SPIE; Vol. 9668).

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

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Combariza ME, Yu X, Nesbitt W, Tovar-Lopez F, Rabus DG, Mitchell A. Dynamic evaluation and control of blood clotting using a microfluidic platform for high-throughput diagnostics. In Palomba S, Eggleton BJ, editors, Micro+Nano Materials, Devices, and Systems. Bellingham WA USA: SPIE. 2015. 96681U. (Proceedings of SPIE). https://doi.org/10.1117/12.2202367