Abstract
Microfluidic technology has the potential to revolutionise blood-clotting diagnostics by incorporating key physiological blood flow conditions like shear rate. In this paper we present a customised dynamic microfluidic system, which evaluates the blood clotting response to multiple conditions of shear rate on a single microchannel. The system can achieve high-throughput testing through use of an advanced fluid control system, which provides with rapid and precise regulation of the blood flow conditions in the platform. We present experimental results that demonstrate the potential of this platform to develop into a high-throughput, low-cost, blood-clotting diagnostics device.
| Original language | English |
|---|---|
| Title of host publication | Micro+Nano Materials, Devices, and Systems |
| Editors | Stefano Palomba, Benjamin J. Eggleton |
| Place of Publication | Bellingham WA USA |
| Publisher | SPIE |
| Number of pages | 10 |
| ISBN (Electronic) | 9781628418903 |
| DOIs | |
| Publication status | Published - 1 Jan 2015 |
| Event | SPIE Micro+Nano Materials, Devices, and Applications Symposium 2015 - The University of Sydney, Sydney, Australia Duration: 6 Dec 2015 → 9 Dec 2015 http://spie.org/conferences-and-exhibitions/micronano-materials-devices-and-applications?SSO=1 |
Publication series
| Name | Proceedings of SPIE |
|---|---|
| Publisher | The International Society for Optical Engineering |
| Volume | 9668 |
| ISSN (Print) | 0277-786X |
| ISSN (Electronic) | 1996-756X |
Conference
| Conference | SPIE Micro+Nano Materials, Devices, and Applications Symposium 2015 |
|---|---|
| Country | Australia |
| City | Sydney |
| Period | 6/12/15 → 9/12/15 |
| Internet address |
Keywords
- automation
- blood clotting
- diagnostics
- Dynamic modelling
- high-throughput
- microuidics
- ow control
Cite this
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Dynamic evaluation and control of blood clotting using a microfluidic platform for high-throughput diagnostics. / Combariza, Miguel E.; Yu, Xinghuo; Nesbitt, Warwick; Tovar-Lopez, Francisco; Rabus, Dominik G.; Mitchell, Arnan.
Micro+Nano Materials, Devices, and Systems. ed. / Stefano Palomba; Benjamin J. Eggleton. Bellingham WA USA : SPIE, 2015. 96681U (Proceedings of SPIE; Vol. 9668).Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review
TY - GEN
T1 - Dynamic evaluation and control of blood clotting using a microfluidic platform for high-throughput diagnostics
AU - Combariza, Miguel E.
AU - Yu, Xinghuo
AU - Nesbitt, Warwick
AU - Tovar-Lopez, Francisco
AU - Rabus, Dominik G.
AU - Mitchell, Arnan
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Microfluidic technology has the potential to revolutionise blood-clotting diagnostics by incorporating key physiological blood flow conditions like shear rate. In this paper we present a customised dynamic microfluidic system, which evaluates the blood clotting response to multiple conditions of shear rate on a single microchannel. The system can achieve high-throughput testing through use of an advanced fluid control system, which provides with rapid and precise regulation of the blood flow conditions in the platform. We present experimental results that demonstrate the potential of this platform to develop into a high-throughput, low-cost, blood-clotting diagnostics device.
AB - Microfluidic technology has the potential to revolutionise blood-clotting diagnostics by incorporating key physiological blood flow conditions like shear rate. In this paper we present a customised dynamic microfluidic system, which evaluates the blood clotting response to multiple conditions of shear rate on a single microchannel. The system can achieve high-throughput testing through use of an advanced fluid control system, which provides with rapid and precise regulation of the blood flow conditions in the platform. We present experimental results that demonstrate the potential of this platform to develop into a high-throughput, low-cost, blood-clotting diagnostics device.
KW - automation
KW - blood clotting
KW - diagnostics
KW - Dynamic modelling
KW - high-throughput
KW - microuidics
KW - ow control
UR - http://www.scopus.com/inward/record.url?scp=84959875650&partnerID=8YFLogxK
U2 - 10.1117/12.2202367
DO - 10.1117/12.2202367
M3 - Conference Paper
T3 - Proceedings of SPIE
BT - Micro+Nano Materials, Devices, and Systems
A2 - Palomba, Stefano
A2 - Eggleton, Benjamin J.
PB - SPIE
CY - Bellingham WA USA
ER -