Dynamic evaluation and control of blood clotting using a microfluidic platform for high-throughput diagnostics

Miguel E. Combariza; Xinghuo Yu; Warwick Nesbitt; Francisco Tovar-Lopez; Dominik G. Rabus; Arnan Mitchell

doi:10.1117/12.2202367

Dynamic evaluation and control of blood clotting using a microfluidic platform for high-throughput diagnostics

Miguel E. Combariza, Xinghuo Yu, Warwick Nesbitt, Francisco Tovar-Lopez, Dominik G. Rabus, Arnan Mitchell

Australian Centre for Blood Diseases

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

Abstract

Microfluidic technology has the potential to revolutionise blood-clotting diagnostics by incorporating key physiological blood flow conditions like shear rate. In this paper we present a customised dynamic microfluidic system, which evaluates the blood clotting response to multiple conditions of shear rate on a single microchannel. The system can achieve high-throughput testing through use of an advanced fluid control system, which provides with rapid and precise regulation of the blood flow conditions in the platform. We present experimental results that demonstrate the potential of this platform to develop into a high-throughput, low-cost, blood-clotting diagnostics device.

Original language	English
Title of host publication	Micro+Nano Materials, Devices, and Systems
Editors	Stefano Palomba, Benjamin J. Eggleton
Place of Publication	Bellingham WA USA
Publisher	SPIE
Number of pages	10
ISBN (Electronic)	9781628418903
DOIs	https://doi.org/10.1117/12.2202367
Publication status	Published - 1 Jan 2015
Event	SPIE Micro+Nano Materials, Devices, and Applications Symposium 2015 - The University of Sydney, Sydney, Australia Duration: 6 Dec 2015 → 9 Dec 2015 http://spie.org/conferences-and-exhibitions/micronano-materials-devices-and-applications?SSO=1

Publication series

Name	Proceedings of SPIE
Publisher	The International Society for Optical Engineering
Volume	9668
ISSN (Print)	0277-786X
ISSN (Electronic)	1996-756X

Conference

Conference	SPIE Micro+Nano Materials, Devices, and Applications Symposium 2015
Country/Territory	Australia
City	Sydney
Period	6/12/15 → 9/12/15
Internet address	http://spie.org/conferences-and-exhibitions/micronano-materials-devices-and-applications?SSO=1

Keywords

automation
blood clotting
diagnostics
Dynamic modelling
high-throughput
microuidics
ow control

Access to Document

10.1117/12.2202367

Cite this

Combariza, M. E., Yu, X., Nesbitt, W., Tovar-Lopez, F., Rabus, D. G., & Mitchell, A. (2015). Dynamic evaluation and control of blood clotting using a microfluidic platform for high-throughput diagnostics. In S. Palomba, & B. J. Eggleton (Eds.), Micro+Nano Materials, Devices, and Systems [96681U] (Proceedings of SPIE; Vol. 9668). SPIE. https://doi.org/10.1117/12.2202367

Combariza, Miguel E. ; Yu, Xinghuo ; Nesbitt, Warwick ; Tovar-Lopez, Francisco ; Rabus, Dominik G. ; Mitchell, Arnan. / Dynamic evaluation and control of blood clotting using a microfluidic platform for high-throughput diagnostics. Micro+Nano Materials, Devices, and Systems. editor / Stefano Palomba ; Benjamin J. Eggleton. Bellingham WA USA : SPIE, 2015. (Proceedings of SPIE).

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title = "Dynamic evaluation and control of blood clotting using a microfluidic platform for high-throughput diagnostics",

abstract = "Microfluidic technology has the potential to revolutionise blood-clotting diagnostics by incorporating key physiological blood flow conditions like shear rate. In this paper we present a customised dynamic microfluidic system, which evaluates the blood clotting response to multiple conditions of shear rate on a single microchannel. The system can achieve high-throughput testing through use of an advanced fluid control system, which provides with rapid and precise regulation of the blood flow conditions in the platform. We present experimental results that demonstrate the potential of this platform to develop into a high-throughput, low-cost, blood-clotting diagnostics device.",

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note = "SPIE Micro+Nano Materials, Devices, and Applications Symposium 2015 ; Conference date: 06-12-2015 Through 09-12-2015",

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Combariza, ME, Yu, X, Nesbitt, W, Tovar-Lopez, F, Rabus, DG & Mitchell, A 2015, Dynamic evaluation and control of blood clotting using a microfluidic platform for high-throughput diagnostics. in S Palomba & BJ Eggleton (eds), Micro+Nano Materials, Devices, and Systems., 96681U, Proceedings of SPIE, vol. 9668, SPIE, Bellingham WA USA, SPIE Micro+Nano Materials, Devices, and Applications Symposium 2015, Sydney, New South Wales, Australia, 6/12/15. https://doi.org/10.1117/12.2202367

Dynamic evaluation and control of blood clotting using a microfluidic platform for high-throughput diagnostics. / Combariza, Miguel E.; Yu, Xinghuo; Nesbitt, Warwick; Tovar-Lopez, Francisco; Rabus, Dominik G.; Mitchell, Arnan.

Micro+Nano Materials, Devices, and Systems. ed. / Stefano Palomba; Benjamin J. Eggleton. Bellingham WA USA : SPIE, 2015. 96681U (Proceedings of SPIE; Vol. 9668).

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

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AB - Microfluidic technology has the potential to revolutionise blood-clotting diagnostics by incorporating key physiological blood flow conditions like shear rate. In this paper we present a customised dynamic microfluidic system, which evaluates the blood clotting response to multiple conditions of shear rate on a single microchannel. The system can achieve high-throughput testing through use of an advanced fluid control system, which provides with rapid and precise regulation of the blood flow conditions in the platform. We present experimental results that demonstrate the potential of this platform to develop into a high-throughput, low-cost, blood-clotting diagnostics device.

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Dynamic evaluation and control of blood clotting using a microfluidic platform for high-throughput diagnostics

Abstract

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Keywords

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