Dynamic control of type I interferon signalling by an integrated network of negative regulators

Rebecca A Porritt, Paul John Hertzog

Research output: Contribution to journalArticleResearchpeer-review

75 Citations (Scopus)

Abstract

Whereas type I interferons (IFNs) have critical roles in protection from pathogens, excessive IFN responses contribute to pathology in both acute and chronic settings, pointing to the importance of balancing activating signals with regulatory mechanisms that appropriately tune the response. Here we review evidence for an integrated network of negative regulators of IFN production and action, which function at all levels of the activating and effector signalling pathways. We propose that the aim of this extensive network is to limit tissue damage while enabling an IFN response that is temporally appropriate and of sufficient magnitude. Understanding the architecture and dynamics of this network, and how it differs in distinct tissues, will provide new insights into IFN biology and aid the design of more effective therapeutics.
Original languageEnglish
Pages (from-to)150 - 160
Number of pages11
JournalTrends in Immunology
Volume36
Issue number3
DOIs
Publication statusPublished - 2015

Cite this

@article{c9215eea48cb48d29327ce28a4c99667,
title = "Dynamic control of type I interferon signalling by an integrated network of negative regulators",
abstract = "Whereas type I interferons (IFNs) have critical roles in protection from pathogens, excessive IFN responses contribute to pathology in both acute and chronic settings, pointing to the importance of balancing activating signals with regulatory mechanisms that appropriately tune the response. Here we review evidence for an integrated network of negative regulators of IFN production and action, which function at all levels of the activating and effector signalling pathways. We propose that the aim of this extensive network is to limit tissue damage while enabling an IFN response that is temporally appropriate and of sufficient magnitude. Understanding the architecture and dynamics of this network, and how it differs in distinct tissues, will provide new insights into IFN biology and aid the design of more effective therapeutics.",
author = "Porritt, {Rebecca A} and Hertzog, {Paul John}",
year = "2015",
doi = "10.1016/j.it.2015.02.002",
language = "English",
volume = "36",
pages = "150 -- 160",
journal = "Trends in Immunology",
issn = "1471-4906",
publisher = "Elsevier",
number = "3",

}

Dynamic control of type I interferon signalling by an integrated network of negative regulators. / Porritt, Rebecca A; Hertzog, Paul John.

In: Trends in Immunology, Vol. 36, No. 3, 2015, p. 150 - 160.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Dynamic control of type I interferon signalling by an integrated network of negative regulators

AU - Porritt, Rebecca A

AU - Hertzog, Paul John

PY - 2015

Y1 - 2015

N2 - Whereas type I interferons (IFNs) have critical roles in protection from pathogens, excessive IFN responses contribute to pathology in both acute and chronic settings, pointing to the importance of balancing activating signals with regulatory mechanisms that appropriately tune the response. Here we review evidence for an integrated network of negative regulators of IFN production and action, which function at all levels of the activating and effector signalling pathways. We propose that the aim of this extensive network is to limit tissue damage while enabling an IFN response that is temporally appropriate and of sufficient magnitude. Understanding the architecture and dynamics of this network, and how it differs in distinct tissues, will provide new insights into IFN biology and aid the design of more effective therapeutics.

AB - Whereas type I interferons (IFNs) have critical roles in protection from pathogens, excessive IFN responses contribute to pathology in both acute and chronic settings, pointing to the importance of balancing activating signals with regulatory mechanisms that appropriately tune the response. Here we review evidence for an integrated network of negative regulators of IFN production and action, which function at all levels of the activating and effector signalling pathways. We propose that the aim of this extensive network is to limit tissue damage while enabling an IFN response that is temporally appropriate and of sufficient magnitude. Understanding the architecture and dynamics of this network, and how it differs in distinct tissues, will provide new insights into IFN biology and aid the design of more effective therapeutics.

UR - http://www.cell.com/trends/immunology/pdf/S1471-4906(15)00018-6.pdf

U2 - 10.1016/j.it.2015.02.002

DO - 10.1016/j.it.2015.02.002

M3 - Article

VL - 36

SP - 150

EP - 160

JO - Trends in Immunology

JF - Trends in Immunology

SN - 1471-4906

IS - 3

ER -