Duration of obesity and incident hypertension in adults from the Framingham Heart Study

Stephanie Kartika Tanamas, Evelyn EE Ling Wong, Kathryn Backholer, Asnawi Abdullah, Rory St John Wolfe, Jan J Barendregt, Anna Peeters

Research output: Contribution to journalArticleResearchpeer-review

Abstract

BACKGROUND:: Previous studies exploring the association between obesity and hypertension generally used a single baseline measurement of obesity. The effect of accumulating excess adiposity over time on the risk of hypertension is uncertain. This study aimed to examine the relationship between duration of obesity and incident hypertension using the Framingham Heart Study. METHODS:: Two thousand, nine hundred and fifty-three participants aged 30-62 years without baseline hypertension were included. Blood pressure, height and weight were measured biennially. Duration of obesity was calculated. Time to incident hypertension was analysed using time-varying Cox proportional hazards regression with age as the time scale and censoring at time of death or end of follow-up. RESULTS:: Eighty percent of participants developed hypertension (median follow-up 15.9 years). A positive association between obesity duration and incident hypertension was observed in women. There was no longer an association when time-varying BMI was adjusted for (hazard ratio 0.95; (95 confidence interval 0.85-1.05)). CONCLUSION:: These findings suggest that the mechanism by which excess adiposity may increase blood pressure is primarily immediate and that long-term exposure to obesity does not further increase the risk of developing hypertension beyond the level of BMI attained
Original languageEnglish
Pages (from-to)542 - 545
Number of pages4
JournalJournal of Hypertension
Volume33
Issue number3
DOIs
Publication statusPublished - 2015

Cite this

@article{5cc18af92a14458a8390fa53bfd3daef,
title = "Duration of obesity and incident hypertension in adults from the Framingham Heart Study",
abstract = "BACKGROUND:: Previous studies exploring the association between obesity and hypertension generally used a single baseline measurement of obesity. The effect of accumulating excess adiposity over time on the risk of hypertension is uncertain. This study aimed to examine the relationship between duration of obesity and incident hypertension using the Framingham Heart Study. METHODS:: Two thousand, nine hundred and fifty-three participants aged 30-62 years without baseline hypertension were included. Blood pressure, height and weight were measured biennially. Duration of obesity was calculated. Time to incident hypertension was analysed using time-varying Cox proportional hazards regression with age as the time scale and censoring at time of death or end of follow-up. RESULTS:: Eighty percent of participants developed hypertension (median follow-up 15.9 years). A positive association between obesity duration and incident hypertension was observed in women. There was no longer an association when time-varying BMI was adjusted for (hazard ratio 0.95; (95 confidence interval 0.85-1.05)). CONCLUSION:: These findings suggest that the mechanism by which excess adiposity may increase blood pressure is primarily immediate and that long-term exposure to obesity does not further increase the risk of developing hypertension beyond the level of BMI attained",
author = "Tanamas, {Stephanie Kartika} and Wong, {Evelyn EE Ling} and Kathryn Backholer and Asnawi Abdullah and Wolfe, {Rory St John} and Barendregt, {Jan J} and Anna Peeters",
year = "2015",
doi = "10.1097/HJH.0000000000000441",
language = "English",
volume = "33",
pages = "542 -- 545",
journal = "Journal of Hypertension",
issn = "0263-6352",
publisher = "Lippincott Williams & Wilkins",
number = "3",

}

Duration of obesity and incident hypertension in adults from the Framingham Heart Study. / Tanamas, Stephanie Kartika; Wong, Evelyn EE Ling; Backholer, Kathryn; Abdullah, Asnawi; Wolfe, Rory St John; Barendregt, Jan J; Peeters, Anna.

In: Journal of Hypertension, Vol. 33, No. 3, 2015, p. 542 - 545.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Duration of obesity and incident hypertension in adults from the Framingham Heart Study

AU - Tanamas, Stephanie Kartika

AU - Wong, Evelyn EE Ling

AU - Backholer, Kathryn

AU - Abdullah, Asnawi

AU - Wolfe, Rory St John

AU - Barendregt, Jan J

AU - Peeters, Anna

PY - 2015

Y1 - 2015

N2 - BACKGROUND:: Previous studies exploring the association between obesity and hypertension generally used a single baseline measurement of obesity. The effect of accumulating excess adiposity over time on the risk of hypertension is uncertain. This study aimed to examine the relationship between duration of obesity and incident hypertension using the Framingham Heart Study. METHODS:: Two thousand, nine hundred and fifty-three participants aged 30-62 years without baseline hypertension were included. Blood pressure, height and weight were measured biennially. Duration of obesity was calculated. Time to incident hypertension was analysed using time-varying Cox proportional hazards regression with age as the time scale and censoring at time of death or end of follow-up. RESULTS:: Eighty percent of participants developed hypertension (median follow-up 15.9 years). A positive association between obesity duration and incident hypertension was observed in women. There was no longer an association when time-varying BMI was adjusted for (hazard ratio 0.95; (95 confidence interval 0.85-1.05)). CONCLUSION:: These findings suggest that the mechanism by which excess adiposity may increase blood pressure is primarily immediate and that long-term exposure to obesity does not further increase the risk of developing hypertension beyond the level of BMI attained

AB - BACKGROUND:: Previous studies exploring the association between obesity and hypertension generally used a single baseline measurement of obesity. The effect of accumulating excess adiposity over time on the risk of hypertension is uncertain. This study aimed to examine the relationship between duration of obesity and incident hypertension using the Framingham Heart Study. METHODS:: Two thousand, nine hundred and fifty-three participants aged 30-62 years without baseline hypertension were included. Blood pressure, height and weight were measured biennially. Duration of obesity was calculated. Time to incident hypertension was analysed using time-varying Cox proportional hazards regression with age as the time scale and censoring at time of death or end of follow-up. RESULTS:: Eighty percent of participants developed hypertension (median follow-up 15.9 years). A positive association between obesity duration and incident hypertension was observed in women. There was no longer an association when time-varying BMI was adjusted for (hazard ratio 0.95; (95 confidence interval 0.85-1.05)). CONCLUSION:: These findings suggest that the mechanism by which excess adiposity may increase blood pressure is primarily immediate and that long-term exposure to obesity does not further increase the risk of developing hypertension beyond the level of BMI attained

UR - http://goo.gl/As2UbD

U2 - 10.1097/HJH.0000000000000441

DO - 10.1097/HJH.0000000000000441

M3 - Article

VL - 33

SP - 542

EP - 545

JO - Journal of Hypertension

JF - Journal of Hypertension

SN - 0263-6352

IS - 3

ER -