Dual crosslinked carboxymethyl sago pulp/pectin hydrogel beads as potential carrier for colon-targeted drug delivery

Hui Li Tan, Li Shan Tan, Yeon Yin Wong, Saravanan Muniyandy, Kamaruddin Hashim, Janarthanan Pushpamalar

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17 Citations (Scopus)

Abstract

Carboxymethyl sago pulp (CMSP)/pectin hydrogel beads were synthesized by calcium crosslinking and further crosslinked by electron beam irradiation to form drug carrier for colon-targeted drug. Sphere-shaped CMSP/pectin 15%/5% hydrogel beads is able to stay intact for 24 h in swelling medium at pH 7.4. It shows pH-sensitive behavior as the swelling degree increases as pH increases. Fourier transform infrared spectroscopy analysis confirmed the absence of chemical interaction between hydrogel beads and diclofenac sodium. Differential scanning calorimetric and X-ray diffraction studies indicate the amorphous nature of entrapped diclofenac sodium. The drug encapsulation efficiency is up to about 50%. Less than 9% of drug has been released at pH 1.2 and the hydrogel beads sustain the drug release at pH 7.4 over 30 h. This shows the potential of CMSP/pectin hydrogel beads as carrier for colon-targeted drug.

Original languageEnglish
Article number43416
Number of pages15
JournalJournal of Applied Polymer Science
Volume133
Issue number19
DOIs
Publication statusPublished - 15 May 2016

Keywords

  • biomedical applications
  • biopolymers and renewable polymers
  • crosslinking
  • drug delivery systems
  • irradiation

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