DSB proteins and bacterial pathogenicity

Begona Heras, Stephen R Shouldice, Makrina Totsika, Martin Scanlon, Mark A Schembri, Jennifer Louise Martin

Research output: Contribution to journalArticleResearchpeer-review

232 Citations (Scopus)


If DNA is the information of life, then proteins are the machines of life - but they must be assembled and correctly folded to function. A key step in the protein-folding pathway is the introduction of disulphide bonds between cysteine residues in a process called oxidative protein folding. Many bacteria use an oxidative protein-folding machinery to assemble proteins that are essential for cell integrity and to produce virulence factors. Although our current knowledge of this machinery stems largely from Escherichia coli K-12, this view must now be adjusted to encompass the wider range of disulphide catalytic systems present in bacteria.
Original languageEnglish
Pages (from-to)215 - 225
Number of pages11
JournalNature Reviews Microbiology
Issue number13
Publication statusPublished - 2009

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