If DNA is the information of life, then proteins are the machines of life - but they must be assembled and correctly folded to function. A key step in the protein-folding pathway is the introduction of disulphide bonds between cysteine residues in a process called oxidative protein folding. Many bacteria use an oxidative protein-folding machinery to assemble proteins that are essential for cell integrity and to produce virulence factors. Although our current knowledge of this machinery stems largely from Escherichia coli K-12, this view must now be adjusted to encompass the wider range of disulphide catalytic systems present in bacteria.
|Pages (from-to)||215 - 225|
|Number of pages||11|
|Journal||Nature Reviews Microbiology|
|Publication status||Published - 2009|