Drug release from nanomedicines: Selection of appropriate encapsulation and release methodology

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Abstract

The characterization of encapsulation efficiency and in vitro drug release from nanoparticle-based formulations often requires the separation of nanoparticles from unencapsulated drug. Inefficient separation of nanoparticles from the medium in which they are dispersed can lead to inaccurate estimates of encapsulation efficiency and drug release. This study establishes dynamic light scattering as a simple method for substantiation of the effectiveness of the separation process. Colistin-loaded liposomes, as an exemplar nanosized delivery particle, were diluted to construct a calibration curve relating the amount of light scattering to liposome concentration.
Original languageEnglish
Pages (from-to)284 - 292
Number of pages9
JournalDrug Delivery and Translational Research
Volume2
DOIs
Publication statusPublished - 2012

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