Drug conjugation to cyclic peptide-polymer self-assembling nanotubes

Bianca M Blunden; Robert Chapman; Maarten Danial; Hongxu Lu; Katrina A Jolliffe; Sebastien Perrier; Martina Heide Stenzel

doi:10.1002/chem.201403130

Drug conjugation to cyclic peptide-polymer self-assembling nanotubes

Bianca M Blunden
, Robert Chapman
, Maarten Danial
, Hongxu Lu
, Katrina A Jolliffe
, Sebastien Perrier
, Martina Heide Stenzel

Drug Delivery Disposition & Dynamics

Research output: Contribution to journal › Article › Research › peer-review

47 Citations (Scopus)

Abstract

We show for the first time how polymeric nanotubes (NTs) based on self-assembled conjugates of polymers and cyclic peptides can be used as an efficient drug carrier. RAPTA-C, a ruthenium-based anticancer drug, was conjugated to a statistical co-polymer based on poly(2-hydroxyethyl acrylate) (pHEA) and poly(2-chloroethyl methacrylate) (pCEMA), which formed the shell of the NTs. Self-assembly into nanotubes (length 200-500nm) led to structures exhibiting high activity against cancer cells.

Original language	English
Pages (from-to)	12745 - 12749
Number of pages	5
Journal	Chemistry - A European Journal
Volume	20
Issue number	40
DOIs	https://doi.org/10.1002/chem.201403130
Publication status	Published - 2014

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10.1002/chem.201403130

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AU - Blunden, Bianca M

AU - Chapman, Robert

AU - Danial, Maarten

AU - Lu, Hongxu

AU - Jolliffe, Katrina A

AU - Perrier, Sebastien

AU - Stenzel, Martina Heide

PY - 2014

Y1 - 2014

N2 - We show for the first time how polymeric nanotubes (NTs) based on self-assembled conjugates of polymers and cyclic peptides can be used as an efficient drug carrier. RAPTA-C, a ruthenium-based anticancer drug, was conjugated to a statistical co-polymer based on poly(2-hydroxyethyl acrylate) (pHEA) and poly(2-chloroethyl methacrylate) (pCEMA), which formed the shell of the NTs. Self-assembly into nanotubes (length 200-500nm) led to structures exhibiting high activity against cancer cells.

AB - We show for the first time how polymeric nanotubes (NTs) based on self-assembled conjugates of polymers and cyclic peptides can be used as an efficient drug carrier. RAPTA-C, a ruthenium-based anticancer drug, was conjugated to a statistical co-polymer based on poly(2-hydroxyethyl acrylate) (pHEA) and poly(2-chloroethyl methacrylate) (pCEMA), which formed the shell of the NTs. Self-assembly into nanotubes (length 200-500nm) led to structures exhibiting high activity against cancer cells.

UR - http://onlinelibrary.wiley.com/doi/10.1002/chem.201403130/epdf

U2 - 10.1002/chem.201403130

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JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

IS - 40

ER -

Drug conjugation to cyclic peptide-polymer self-assembling nanotubes

Abstract

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