Drimane sesquiterpene-conjugated amino acids from a marine isolate of the fungus Talaromyces minioluteus (Penicillium Minioluteum)

Suthatip Ngokpol; Wittaya Suwakulsiri; Sanya Sureram; Kriengsak Lirdprapamongkol; Thammarat Aree; Suthep Wiyakrutta; Chulabhorn Mahidol; Somsak Ruchirawat; Prasat Kittakoop

doi:10.3390/md13063567

Drimane sesquiterpene-conjugated amino acids from a marine isolate of the fungus Talaromyces minioluteus (Penicillium Minioluteum)

Suthatip Ngokpol, Wittaya Suwakulsiri, Sanya Sureram, Kriengsak Lirdprapamongkol, Thammarat Aree, Suthep Wiyakrutta, Chulabhorn Mahidol, Somsak Ruchirawat, Prasat Kittakoop

Research output: Contribution to journal › Article › Research › peer-review

37 Citations (Scopus)

Abstract

Four new sesquiterpene lactones (3, 4, 6 and 7) and three known compounds, purpuride (1), berkedrimane B (2) and purpuride B (5), were isolated from the marine fungus, Talaromyces minioluteus (Penicillium minioluteum). New compounds were drimane sesquiterpenes conjugated with N-acetyl-L-valine, and their structures were elucidated by analysis of spectroscopic data, as well as by single crystal X-ray analysis. The isolated compounds could not inhibit the apoptosis-regulating enzyme, caspase-3, while three of the compounds (2, 3 and 7) exhibited weak cytotoxic activity.

Original language	English
Pages (from-to)	3567-3580
Number of pages	14
Journal	Marine Drugs
Volume	13
Issue number	6
DOIs	https://doi.org/10.3390/md13063567
Publication status	Published - Jun 2015
Externally published	Yes

Keywords

Caspase-3
Cytotoxic activity
Drimane
Fungal metabolites
Marine fungi
Penicillium minioluteum
Sesquiterpene
Talaromyces minioluteus

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/md13063567Licence: CC BY

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title = "Drimane sesquiterpene-conjugated amino acids from a marine isolate of the fungus Talaromyces minioluteus (Penicillium Minioluteum)",

abstract = "Four new sesquiterpene lactones (3, 4, 6 and 7) and three known compounds, purpuride (1), berkedrimane B (2) and purpuride B (5), were isolated from the marine fungus, Talaromyces minioluteus (Penicillium minioluteum). New compounds were drimane sesquiterpenes conjugated with N-acetyl-L-valine, and their structures were elucidated by analysis of spectroscopic data, as well as by single crystal X-ray analysis. The isolated compounds could not inhibit the apoptosis-regulating enzyme, caspase-3, while three of the compounds (2, 3 and 7) exhibited weak cytotoxic activity.",

keywords = "Caspase-3, Cytotoxic activity, Drimane, Fungal metabolites, Marine fungi, Penicillium minioluteum, Sesquiterpene, Talaromyces minioluteus",

author = "Suthatip Ngokpol and Wittaya Suwakulsiri and Sanya Sureram and Kriengsak Lirdprapamongkol and Thammarat Aree and Suthep Wiyakrutta and Chulabhorn Mahidol and Somsak Ruchirawat and Prasat Kittakoop",

year = "2015",

month = jun,

doi = "10.3390/md13063567",

language = "English",

volume = "13",

pages = "3567--3580",

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T1 - Drimane sesquiterpene-conjugated amino acids from a marine isolate of the fungus Talaromyces minioluteus (Penicillium Minioluteum)

AU - Ngokpol, Suthatip

AU - Suwakulsiri, Wittaya

AU - Sureram, Sanya

AU - Lirdprapamongkol, Kriengsak

AU - Aree, Thammarat

AU - Wiyakrutta, Suthep

AU - Mahidol, Chulabhorn

AU - Ruchirawat, Somsak

AU - Kittakoop, Prasat

PY - 2015/6

Y1 - 2015/6

N2 - Four new sesquiterpene lactones (3, 4, 6 and 7) and three known compounds, purpuride (1), berkedrimane B (2) and purpuride B (5), were isolated from the marine fungus, Talaromyces minioluteus (Penicillium minioluteum). New compounds were drimane sesquiterpenes conjugated with N-acetyl-L-valine, and their structures were elucidated by analysis of spectroscopic data, as well as by single crystal X-ray analysis. The isolated compounds could not inhibit the apoptosis-regulating enzyme, caspase-3, while three of the compounds (2, 3 and 7) exhibited weak cytotoxic activity.

AB - Four new sesquiterpene lactones (3, 4, 6 and 7) and three known compounds, purpuride (1), berkedrimane B (2) and purpuride B (5), were isolated from the marine fungus, Talaromyces minioluteus (Penicillium minioluteum). New compounds were drimane sesquiterpenes conjugated with N-acetyl-L-valine, and their structures were elucidated by analysis of spectroscopic data, as well as by single crystal X-ray analysis. The isolated compounds could not inhibit the apoptosis-regulating enzyme, caspase-3, while three of the compounds (2, 3 and 7) exhibited weak cytotoxic activity.

KW - Caspase-3

KW - Cytotoxic activity

KW - Drimane

KW - Fungal metabolites

KW - Marine fungi

KW - Penicillium minioluteum

KW - Sesquiterpene

KW - Talaromyces minioluteus

UR - http://www.scopus.com/inward/record.url?scp=84936803391&partnerID=8YFLogxK

U2 - 10.3390/md13063567

DO - 10.3390/md13063567

M3 - Article

C2 - 26058010

AN - SCOPUS:84936803391

SN - 1660-3397

VL - 13

SP - 3567

EP - 3580

JO - Marine Drugs

JF - Marine Drugs

IS - 6

ER -

Drimane sesquiterpene-conjugated amino acids from a marine isolate of the fungus Talaromyces minioluteus (Penicillium Minioluteum)

Abstract

Keywords

UN SDGs

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