Draft genome sequence of a multidrug-resistant KPC-2-producing Enterobacter aerogenes isolated from a hospitalised patient in Brazil

Quézia Moura, Miriam R. Fernandes, Louise Cerdeira, Lúcia F. Nhambe, Susan Ienne, Tiago A. Souza, Nilton Lincopan

Research output: Contribution to journalComment / DebateOtherpeer-review

1 Citation (Scopus)

Abstract

Objectives Multidrug-resistant (MDR) Enterobacter aerogenes strains are frequently associated with nosocomial infections and high mortality rates, representing a serious public health problem. The aim of this study was to present the draft genome sequence of a MDR KPC-2-producing E. aerogenes isolated from a perineal swab of a hospitalised patient in Brazil. Methods Genomic DNA was sequenced using an Illumina MiSeq platform. De novo genome assembly was carried out using the A5-Miseq pipeline, and whole-genome sequence analysis was performed using tools from the Center for Genomic Epidemiology. Results The strain harboured resistance genes to β-lactams, aminoglycosides, sulphonamides and trimethoprim in addition to genes encoding multidrug efflux system proteins, a quaternary ammonium transporter and heavy metal efflux system proteins. In addition, the strain harboured genes encoding diverse virulence factors. Conclusion These data might allow a better understanding of the genetic basis of antimicrobial resistance and virulence in E. aerogenes strains.

Original languageEnglish
Pages (from-to)277-278
Number of pages2
JournalJournal of Global Antimicrobial Resistance
Volume10
DOIs
Publication statusPublished - Sep 2017
Externally publishedYes

Keywords

  • bla
  • Efflux pumps
  • Enterobacter aerogenes
  • Heavy metal resistance
  • Whole-genome sequencing

Cite this