Doxycycline and Sitafloxacin Combination Therapy for Treating Highly Resistant Mycoplasma genitalium

Duygu Durukan; Michelle Doyle; Gerald Murray; Kaveesha Bodiyabadu; Lenka Vodstrcil; Eric P.F. Chow; Jorgen S. Jensen; Christopher K. Fairley; Ivette Aguirre; Catriona S. Bradshaw

doi:10.3201/eid2608.191806

Doxycycline and Sitafloxacin Combination Therapy for Treating Highly Resistant Mycoplasma genitalium

Duygu Durukan, Michelle Doyle, Gerald Murray, Kaveesha Bodiyabadu, Lenka Vodstrcil, Eric P.F. Chow, Jorgen S. Jensen, Christopher K. Fairley, Ivette Aguirre, Catriona S. Bradshaw

Research output: Contribution to journal › Article › Research › peer-review

8 Citations (Scopus)

Abstract

Antimicrobial-resistant Mycoplasma genitalium is becoming increasingly common and creating major treatment challenges. We present early data on combination therapy with doxycycline and sitafloxacin to treat highly resistant M. genitalium. We found the regimen was well tolerated and cured 11/12 infections that had failed prior regimens with moxifloxacin and pristinamycin.

Original language	English
Pages (from-to)	1870-1874
Number of pages	5
Journal	Emerging Infectious Diseases
Volume	26
Issue number	8
DOIs	https://doi.org/10.3201/eid2608.191806
Publication status	Published - Aug 2020

Keywords

AMR
antimicrobial resistance
doxycycline
dual-class resistance
macrolide resistance
multidrug resistance
Mycoplasma genitalium
quinolone resistance
sexually transmitted infections
sitafloxacin

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3201/eid2608.191806

315790103-oaFinal published version, 1.95 MB

Cite this

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title = "Doxycycline and Sitafloxacin Combination Therapy for Treating Highly Resistant Mycoplasma genitalium",

abstract = "Antimicrobial-resistant Mycoplasma genitalium is becoming increasingly common and creating major treatment challenges. We present early data on combination therapy with doxycycline and sitafloxacin to treat highly resistant M. genitalium. We found the regimen was well tolerated and cured 11/12 infections that had failed prior regimens with moxifloxacin and pristinamycin.",

keywords = "AMR, antimicrobial resistance, doxycycline, dual-class resistance, macrolide resistance, multidrug resistance, Mycoplasma genitalium, quinolone resistance, sexually transmitted infections, sitafloxacin",

author = "Duygu Durukan and Michelle Doyle and Gerald Murray and Kaveesha Bodiyabadu and Lenka Vodstrcil and Chow, {Eric P.F.} and Jensen, {Jorgen S.} and Fairley, {Christopher K.} and Ivette Aguirre and Bradshaw, {Catriona S.}",

year = "2020",

month = aug,

doi = "10.3201/eid2608.191806",

language = "English",

volume = "26",

pages = "1870--1874",

journal = "Emerging Infectious Diseases",

issn = "1080-6040",

publisher = "Centers for Disease Control and Prevention (CDC)",

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TY - JOUR

T1 - Doxycycline and Sitafloxacin Combination Therapy for Treating Highly Resistant Mycoplasma genitalium

AU - Durukan, Duygu

AU - Doyle, Michelle

AU - Murray, Gerald

AU - Bodiyabadu, Kaveesha

AU - Vodstrcil, Lenka

AU - Chow, Eric P.F.

AU - Jensen, Jorgen S.

AU - Fairley, Christopher K.

AU - Aguirre, Ivette

AU - Bradshaw, Catriona S.

PY - 2020/8

Y1 - 2020/8

N2 - Antimicrobial-resistant Mycoplasma genitalium is becoming increasingly common and creating major treatment challenges. We present early data on combination therapy with doxycycline and sitafloxacin to treat highly resistant M. genitalium. We found the regimen was well tolerated and cured 11/12 infections that had failed prior regimens with moxifloxacin and pristinamycin.

AB - Antimicrobial-resistant Mycoplasma genitalium is becoming increasingly common and creating major treatment challenges. We present early data on combination therapy with doxycycline and sitafloxacin to treat highly resistant M. genitalium. We found the regimen was well tolerated and cured 11/12 infections that had failed prior regimens with moxifloxacin and pristinamycin.

KW - AMR

KW - antimicrobial resistance

KW - doxycycline

KW - dual-class resistance

KW - macrolide resistance

KW - multidrug resistance

KW - Mycoplasma genitalium

KW - quinolone resistance

KW - sexually transmitted infections

KW - sitafloxacin

UR - http://www.scopus.com/inward/record.url?scp=85088351246&partnerID=8YFLogxK

U2 - 10.3201/eid2608.191806

DO - 10.3201/eid2608.191806

M3 - Article

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AN - SCOPUS:85088351246

VL - 26

SP - 1870

EP - 1874

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

SN - 1080-6040

IS - 8

ER -

Doxycycline and Sitafloxacin Combination Therapy for Treating Highly Resistant Mycoplasma genitalium

Abstract

Keywords

UN SDGs

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Prevalence of Genital HPV Infection in Males Following Introduction of Universal Male HPV Vaccination

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Doxycycline and Sitafloxacin Combination Therapy for Treating Highly Resistant Mycoplasma genitalium

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Projects

Prevalence of Genital HPV Infection in Males Following Introduction of Universal Male HPV Vaccination

Cite this