Doxycycline and Sitafloxacin Combination Therapy for Treating Highly Resistant Mycoplasma genitalium

Duygu Durukan, Michelle Doyle, Gerald Murray, Kaveesha Bodiyabadu, Lenka Vodstrcil, Eric P.F. Chow, Jorgen S. Jensen, Christopher K. Fairley, Ivette Aguirre, Catriona S. Bradshaw

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Antimicrobial-resistant Mycoplasma genitalium is becoming increasingly common and creating major treatment challenges. We present early data on combination therapy with doxycycline and sitafloxacin to treat highly resistant M. genitalium. We found the regimen was well tolerated and cured 11/12 infections that had failed prior regimens with moxifloxacin and pristinamycin.

Original languageEnglish
Pages (from-to)1870-1874
Number of pages5
JournalEmerging Infectious Diseases
Volume26
Issue number8
DOIs
Publication statusPublished - Aug 2020

Keywords

  • AMR
  • antimicrobial resistance
  • doxycycline
  • dual-class resistance
  • macrolide resistance
  • multidrug resistance
  • Mycoplasma genitalium
  • quinolone resistance
  • sexually transmitted infections
  • sitafloxacin

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