Doxorubicin-conjugated PEGylated dendrimers show similar tumoricidal activity but lower systemic toxicity when compared to PEGylated liposome and solution formulations in mouse and rat tumour models

Lisa Michelle Kaminskas, Victoria Mary McLeod, Brian D Kelly, Carleen M Cullinane, Gian Sberna, Mark Williamson, Benjamin James Boyd, David J Owen, Christopher John Porter

Research output: Contribution to journalArticleResearchpeer-review

57 Citations (Scopus)

Abstract

PEGylated polylysine dendrimers show promise as novel drug delivery systems with the potential to direct site specific deposition patterns and to reduce toxicity at nontarget sites.
Original languageEnglish
Pages (from-to)422 - 432
Number of pages11
JournalMolecular Pharmaceutics
Volume9
Issue number3
DOIs
Publication statusPublished - 2012

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