double-time is identical to discs overgrown, which is required for cell survival, proliferation and growth arrest in Drosophila imaginal discs

Olav Zilian, Erich Frei, Richard Burke, Doris Brentrup, Thomas Gutjahr, Peter J. Bryant, Markus Noll

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68 Citations (Scopus)


We have isolated the discs overgrown gene of Drosophila and shown that it encodes a homolog of the Casein kinase Iδ/ε subfamily and is identical to the double-time gene. However, in contrast to the weak double-time alleles, which appear to affect only the circadian rhythm, discs overgrown alleles, including bona fide null alleles, show strong effects on cell survival and growth control in imaginal discs. Analysis of their phenotypes and molecular lesions suggests that the Discs overgrown protein is a crucial component in the mechanism that links cell survival during proliferation to growth arrest in imaginal discs. This work provides the first analysis in a multicellular organism of Casein kinase Iδ/ε functions necessary for survival. Since the amino acid sequences and three-dimensional structures of Casein kinase Iδ/ε enzymes are highly conserved, the results suggest that these proteins may also function in controlling cell growth and survival in other organisms.

Original languageEnglish
Pages (from-to)5409-5420
Number of pages12
Issue number23
Publication statusPublished - 1 Dec 1999
Externally publishedYes


  • Casein kinase Iδ/ε
  • Cell survival
  • discs overgrown
  • Drosophila melanogaster
  • Growth arrest
  • Imaginal discs

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