Double-blind, randomized, placebo-controlled study of high-dose HMG CoA reductase inhibitor therapy on ventricular remodeling, pro-inflammatory cytokines and neurohormonal parameters in patients with chronic systolic heart failure

Henry Krum, Emma Louise Ashton, Christopher Michael Reid, Victor Kalff, Jim Rogers, John Amarena, Bhuwan Singh, Andrew Maxwell Tonkin

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Abstract

Background: Statins decrease mortality in patients with coronary artery disease. However, chronic heart failure (CHF) patients were often excluded in such trials. Statins possess pharmacologic properties (independent of cholesterol lowering) that may be beneficial on ventricular remodeling in such patients. Methods and Results: We conducted a 6-month randomized placebo (PBO)-controlled study of rosuvastatin (ROS) in patients with systolic (left ventricular ejection fraction [LVEF]
Original languageEnglish
Pages (from-to)1 - 7
Number of pages7
JournalJournal of Cardiac Failure
Volume13
Issue number1
Publication statusPublished - 2007

Cite this

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title = "Double-blind, randomized, placebo-controlled study of high-dose HMG CoA reductase inhibitor therapy on ventricular remodeling, pro-inflammatory cytokines and neurohormonal parameters in patients with chronic systolic heart failure",
abstract = "Background: Statins decrease mortality in patients with coronary artery disease. However, chronic heart failure (CHF) patients were often excluded in such trials. Statins possess pharmacologic properties (independent of cholesterol lowering) that may be beneficial on ventricular remodeling in such patients. Methods and Results: We conducted a 6-month randomized placebo (PBO)-controlled study of rosuvastatin (ROS) in patients with systolic (left ventricular ejection fraction [LVEF]",
author = "Henry Krum and Ashton, {Emma Louise} and Reid, {Christopher Michael} and Victor Kalff and Jim Rogers and John Amarena and Bhuwan Singh and Tonkin, {Andrew Maxwell}",
year = "2007",
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journal = "Journal of Cardiac Failure",
issn = "1071-9164",
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T1 - Double-blind, randomized, placebo-controlled study of high-dose HMG CoA reductase inhibitor therapy on ventricular remodeling, pro-inflammatory cytokines and neurohormonal parameters in patients with chronic systolic heart failure

AU - Krum, Henry

AU - Ashton, Emma Louise

AU - Reid, Christopher Michael

AU - Kalff, Victor

AU - Rogers, Jim

AU - Amarena, John

AU - Singh, Bhuwan

AU - Tonkin, Andrew Maxwell

PY - 2007

Y1 - 2007

N2 - Background: Statins decrease mortality in patients with coronary artery disease. However, chronic heart failure (CHF) patients were often excluded in such trials. Statins possess pharmacologic properties (independent of cholesterol lowering) that may be beneficial on ventricular remodeling in such patients. Methods and Results: We conducted a 6-month randomized placebo (PBO)-controlled study of rosuvastatin (ROS) in patients with systolic (left ventricular ejection fraction [LVEF]

AB - Background: Statins decrease mortality in patients with coronary artery disease. However, chronic heart failure (CHF) patients were often excluded in such trials. Statins possess pharmacologic properties (independent of cholesterol lowering) that may be beneficial on ventricular remodeling in such patients. Methods and Results: We conducted a 6-month randomized placebo (PBO)-controlled study of rosuvastatin (ROS) in patients with systolic (left ventricular ejection fraction [LVEF]

UR - http://www.elsevier.com/locate/cardfail

M3 - Article

VL - 13

SP - 1

EP - 7

JO - Journal of Cardiac Failure

JF - Journal of Cardiac Failure

SN - 1071-9164

IS - 1

ER -