Double antiangiogenic protein, DAAP, targeting VEGF-A and angiopoietins in tumor angiogenesis, metastasis, and vascular leakage

Young Jun Koh, Hak Zoo Kim, Seong Ik Hwang, Jeung Eun Lee, Nuri Oh, Keehoon Jung, Minah Kim, Kyung Eun Kim, Homin Kim, Nam Kyu Lim, Choon Ju Jeon, Gyun Min Lee, Byeong Hwa Jeon, Do Hyun Nam, Hoon Ki Sung, Andras Nagy, Ook Joon Yoo, Gou Young Koh

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Abstract

Two vascular growth factor families, VEGF and the angiopoietins, play critical and coordinate roles in tumor progression and metastasis. A single inhibitor targeting both VEGF and angiopoietins is not available. Here, we developed a chimeric decoy receptor, namely double anti-angiogenic protein (DAAP), which can simultaneously bind VEGF-A and angiopoietins, blocking their actions. Compared to VEGF-Trap or Tie2-Fc, which block either VEGF-A or angiopoietins alone, we believe DAAP is a highly effective molecule for regressing tumor angiogenesis and metastasis in implanted and spontaneous solid tumors; it can also effectively reduce ascites formation and vascular leakage in an ovarian carcinoma model. Thus, simultaneous blockade of VEGF-A and angiopoietins with DAAP is an effective therapeutic strategy for blocking tumor angiogenesis, metastasis, and vascular leakage.

Original languageEnglish
Pages (from-to)171-184
Number of pages14
JournalCancer Cell
Volume18
Issue number2
DOIs
Publication statusPublished - Aug 2010
Externally publishedYes

Keywords

  • Cellcycle

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