Doripenem

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Abstract

Doripenem (formerly S-4661), (4R,5S,6S)-3-{[(3S,5S)-5- (sulfamoyla-minomethyl)-pyrrolidin-3-yl]thio}-6-[(1R)-1- hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo (3.2.0) hept-2-ene- 2-carboxylic acid (molecular formula, C15H24N4O6S2; molecular weight, 420.50426) is a synthetic 1-beta-methylcarbapenem developed by Shionogi & Co. Ltd. (Osaka, Japan) (Iso et al., 1996). The chemical structure of doripenem is similar to that of meropenem (Anderson, 2006) (see Figure 39.1). In doripenem, the dimethylcarbamoyl side chain of meropenem is replaced by a sulfamoylaminomethyl group (Jones et al., 2004b; Anderson, 2006).

Original languageEnglish
Title of host publicationKucers the Use of Antibiotics
Subtitle of host publicationA Clinical Review of Antibacterial, Antifungal, Antiparasitic, and Antiviral Drugs, Seventh Edition
EditorsM. Lindsay Grayson
Place of PublicationBoca Raton FL USA
PublisherCRC Press
Chapter39
Pages723-742
Number of pages20
Edition7th
ISBN (Electronic)9781498747967
ISBN (Print)9781498747950
DOIs
Publication statusPublished - 2017

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