Dopaminergic haplotype as a predictor of spatial inattention in children with attention-deficit/hyperactivity disorder

Mark Andrew Bellgrove, Katherine A Johnson, Edwina Barry, Aisling Mulligan, Ziarih Hawi, Michael Gill, Ian H Robertson, Christopher D Chambers

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33 Citations (Scopus)

Abstract

A distinct pattern of selective attention deficits in attention-deficit/hyperactivity disorder (ADHD) has been difficult to identify. Heterogeneity may reflect differences in underlying genetics. Objective: To document an objective deficit of selective attention in a large sample of children with and without ADHD using spatial orienting paradigms. By stratifying samples according to the gene dosage of a risk haplotype of the dopamine transporter gene (DAT1), we could determine whether genetic factors predict spatial inattention in ADHD.
Original languageEnglish
Pages (from-to)1135 - 1142
Number of pages8
JournalArchives of General Psychiatry
Volume66
Issue number10
DOIs
Publication statusPublished - 2009
Externally publishedYes

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