Dopamine transporter genotype is associated with a lateralized resistance to distraction during attention selection

Daniel Patrick Newman, Tarrant Cummins, Janette Ho Shuen Tong, Beth Patricia Johnson, Hayley Pickering, Peter Fanning, Joseph Wagner, Jack T T Goodrich, Ziarih Hawi, Christopher D Chambers, Mark Andrew Bellgrove

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Abstract

Although lateral asymmetries in orienting behavior are evident across species and have been linked to interhemispheric asymmetries in dopamine signaling, the relative contribution of attentional versus motoric processes remains unclear. Here we took a cognitive genetic approach to adjudicate between roles for dopamine in attentional versus response selection. A sample of nonclinical adult humans (N = 518) performed three cognitive tasks (spatial attentional competition, spatial cueing, and flanker tasks) that varied in the degree to which they required participants to resolve attentional or response competition. All participants were genotyped for two putatively functional tandem repeat polymorphisms of the dopamine transporter gene (DAT1; SLC6A3), which are argued to influence the level of available synaptic dopamine and confer risk to disorders of inattention. DAT1 genotype modulated the task-specific effects of the various task-irrelevant stimuli across both the spatial competition and spatial cueing but not flanker tasks. Specifically, compared with individuals carrying one or two copies of the 10-repeat DAT1 allele, individuals without this allele demonstrated an immunity to distraction, such that response times were unaffected by increases in the number of distractor stimuli, particularly when these were presented predominantly in the left hemifield. All three genotype groups exhibited uniform costs of resolving leftward response selection in a standard flanker task. None of these significant effects could be explained by speed?accuracy trade-offs, suggesting that participants without the 10-repeat allele of the DAT1 tandem repeat polymorphism possess an enhanced attentional ability to suppress task-irrelevant stimuli in the left hemifield.
Original languageEnglish
Pages (from-to)15743 - 15750
Number of pages8
JournalJournal of Neuroscience
Volume34
Issue number47
DOIs
Publication statusPublished - 2014

Cite this

Newman, Daniel Patrick ; Cummins, Tarrant ; Tong, Janette Ho Shuen ; Johnson, Beth Patricia ; Pickering, Hayley ; Fanning, Peter ; Wagner, Joseph ; Goodrich, Jack T T ; Hawi, Ziarih ; Chambers, Christopher D ; Bellgrove, Mark Andrew. / Dopamine transporter genotype is associated with a lateralized resistance to distraction during attention selection. In: Journal of Neuroscience. 2014 ; Vol. 34, No. 47. pp. 15743 - 15750.
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abstract = "Although lateral asymmetries in orienting behavior are evident across species and have been linked to interhemispheric asymmetries in dopamine signaling, the relative contribution of attentional versus motoric processes remains unclear. Here we took a cognitive genetic approach to adjudicate between roles for dopamine in attentional versus response selection. A sample of nonclinical adult humans (N = 518) performed three cognitive tasks (spatial attentional competition, spatial cueing, and flanker tasks) that varied in the degree to which they required participants to resolve attentional or response competition. All participants were genotyped for two putatively functional tandem repeat polymorphisms of the dopamine transporter gene (DAT1; SLC6A3), which are argued to influence the level of available synaptic dopamine and confer risk to disorders of inattention. DAT1 genotype modulated the task-specific effects of the various task-irrelevant stimuli across both the spatial competition and spatial cueing but not flanker tasks. Specifically, compared with individuals carrying one or two copies of the 10-repeat DAT1 allele, individuals without this allele demonstrated an immunity to distraction, such that response times were unaffected by increases in the number of distractor stimuli, particularly when these were presented predominantly in the left hemifield. All three genotype groups exhibited uniform costs of resolving leftward response selection in a standard flanker task. None of these significant effects could be explained by speed?accuracy trade-offs, suggesting that participants without the 10-repeat allele of the DAT1 tandem repeat polymorphism possess an enhanced attentional ability to suppress task-irrelevant stimuli in the left hemifield.",
author = "Newman, {Daniel Patrick} and Tarrant Cummins and Tong, {Janette Ho Shuen} and Johnson, {Beth Patricia} and Hayley Pickering and Peter Fanning and Joseph Wagner and Goodrich, {Jack T T} and Ziarih Hawi and Chambers, {Christopher D} and Bellgrove, {Mark Andrew}",
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Dopamine transporter genotype is associated with a lateralized resistance to distraction during attention selection. / Newman, Daniel Patrick; Cummins, Tarrant; Tong, Janette Ho Shuen; Johnson, Beth Patricia; Pickering, Hayley; Fanning, Peter; Wagner, Joseph; Goodrich, Jack T T; Hawi, Ziarih; Chambers, Christopher D; Bellgrove, Mark Andrew.

In: Journal of Neuroscience, Vol. 34, No. 47, 2014, p. 15743 - 15750.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Newman, Daniel Patrick

AU - Cummins, Tarrant

AU - Tong, Janette Ho Shuen

AU - Johnson, Beth Patricia

AU - Pickering, Hayley

AU - Fanning, Peter

AU - Wagner, Joseph

AU - Goodrich, Jack T T

AU - Hawi, Ziarih

AU - Chambers, Christopher D

AU - Bellgrove, Mark Andrew

PY - 2014

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N2 - Although lateral asymmetries in orienting behavior are evident across species and have been linked to interhemispheric asymmetries in dopamine signaling, the relative contribution of attentional versus motoric processes remains unclear. Here we took a cognitive genetic approach to adjudicate between roles for dopamine in attentional versus response selection. A sample of nonclinical adult humans (N = 518) performed three cognitive tasks (spatial attentional competition, spatial cueing, and flanker tasks) that varied in the degree to which they required participants to resolve attentional or response competition. All participants were genotyped for two putatively functional tandem repeat polymorphisms of the dopamine transporter gene (DAT1; SLC6A3), which are argued to influence the level of available synaptic dopamine and confer risk to disorders of inattention. DAT1 genotype modulated the task-specific effects of the various task-irrelevant stimuli across both the spatial competition and spatial cueing but not flanker tasks. Specifically, compared with individuals carrying one or two copies of the 10-repeat DAT1 allele, individuals without this allele demonstrated an immunity to distraction, such that response times were unaffected by increases in the number of distractor stimuli, particularly when these were presented predominantly in the left hemifield. All three genotype groups exhibited uniform costs of resolving leftward response selection in a standard flanker task. None of these significant effects could be explained by speed?accuracy trade-offs, suggesting that participants without the 10-repeat allele of the DAT1 tandem repeat polymorphism possess an enhanced attentional ability to suppress task-irrelevant stimuli in the left hemifield.

AB - Although lateral asymmetries in orienting behavior are evident across species and have been linked to interhemispheric asymmetries in dopamine signaling, the relative contribution of attentional versus motoric processes remains unclear. Here we took a cognitive genetic approach to adjudicate between roles for dopamine in attentional versus response selection. A sample of nonclinical adult humans (N = 518) performed three cognitive tasks (spatial attentional competition, spatial cueing, and flanker tasks) that varied in the degree to which they required participants to resolve attentional or response competition. All participants were genotyped for two putatively functional tandem repeat polymorphisms of the dopamine transporter gene (DAT1; SLC6A3), which are argued to influence the level of available synaptic dopamine and confer risk to disorders of inattention. DAT1 genotype modulated the task-specific effects of the various task-irrelevant stimuli across both the spatial competition and spatial cueing but not flanker tasks. Specifically, compared with individuals carrying one or two copies of the 10-repeat DAT1 allele, individuals without this allele demonstrated an immunity to distraction, such that response times were unaffected by increases in the number of distractor stimuli, particularly when these were presented predominantly in the left hemifield. All three genotype groups exhibited uniform costs of resolving leftward response selection in a standard flanker task. None of these significant effects could be explained by speed?accuracy trade-offs, suggesting that participants without the 10-repeat allele of the DAT1 tandem repeat polymorphism possess an enhanced attentional ability to suppress task-irrelevant stimuli in the left hemifield.

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DO - 10.1523/JNEUROSCI.2327-14.2014

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JO - Journal of Neuroscience

JF - Journal of Neuroscience

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