Domino heck-aza-michael reactions: efficient access to 1-substituted tetrahydro-b-carbolines

Daniel Priebbenow, Luke C Henderson, Frederick Matthew Pfeffer, Scott G Stewart

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43 Citations (Scopus)


Chemical Equation Presentation A simple and efficient palladium-catalyzed domino reaction for the synthesis of a series of C1-substituted tetrahydro-?-carbolines is described. This domino process involves a Heck reaction at the indole 2-position of a halogenated tryptamine precursor, followed by intramolecular aza-Michael addition.
Original languageEnglish
Pages (from-to)1787 - 1790
Number of pages4
JournalThe Journal of Organic Chemistry
Issue number5
Publication statusPublished - 2010
Externally publishedYes

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