Domino heck-aza-michael reactions: efficient access to 1-substituted tetrahydro-b-carbolines

Daniel Priebbenow, Luke C Henderson, Frederick Matthew Pfeffer, Scott G Stewart

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

Abstract

Chemical Equation Presentation A simple and efficient palladium-catalyzed domino reaction for the synthesis of a series of C1-substituted tetrahydro-?-carbolines is described. This domino process involves a Heck reaction at the indole 2-position of a halogenated tryptamine precursor, followed by intramolecular aza-Michael addition.
Original languageEnglish
Pages (from-to)1787 - 1790
Number of pages4
JournalThe Journal of Organic Chemistry
Volume75
Issue number5
DOIs
Publication statusPublished - 2010
Externally publishedYes

Cite this