Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrin aIIb{beta}3 in mice

Sascha Claire Hughan, Christopher Mitchell Spring, Simone Marianne Schoenwaelder, Sharelle Anne Sturgeon, Imala Alwis, Yu-Ping Yuan, James David McFadyen, Erik Westein, Duncan Martin Goddard, Akiko Ono, Yuji Yamanashi, Warwick Scott Nesbitt, Shaun Jackson

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Abstract

Background: Dok proteins are negative regulators of immunoreceptor signaling and, potentially, integrin adhesion receptors. Results: Deficiency of Dok-2 results in enhanced shear-dependent integrin adhesion in platelets, leading to accelerated platelet thrombus growth. Conclusion: Dok-2 is a shear-specific negative regulator of blood clot formation. Significance: Dok-2 regulates biomechanical platelet adhesion, and targeting this molecule may provide new avenues to regulate thrombosis. ? 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
Original languageEnglish
Pages (from-to)5051 - 5060
Number of pages10
JournalJournal of Biological Chemistry
Volume289
Issue number8
DOIs
Publication statusPublished - 2014

Cite this

Hughan, S. C., Spring, C. M., Schoenwaelder, S. M., Sturgeon, S. A., Alwis, I., Yuan, Y-P., ... Jackson, S. (2014). Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrin aIIb{beta}3 in mice. Journal of Biological Chemistry, 289(8), 5051 - 5060. https://doi.org/10.1074/jbc.M113.520148
Hughan, Sascha Claire ; Spring, Christopher Mitchell ; Schoenwaelder, Simone Marianne ; Sturgeon, Sharelle Anne ; Alwis, Imala ; Yuan, Yu-Ping ; McFadyen, James David ; Westein, Erik ; Goddard, Duncan Martin ; Ono, Akiko ; Yamanashi, Yuji ; Nesbitt, Warwick Scott ; Jackson, Shaun. / Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrin aIIb{beta}3 in mice. In: Journal of Biological Chemistry. 2014 ; Vol. 289, No. 8. pp. 5051 - 5060.
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title = "Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrin aIIb{beta}3 in mice",
abstract = "Background: Dok proteins are negative regulators of immunoreceptor signaling and, potentially, integrin adhesion receptors. Results: Deficiency of Dok-2 results in enhanced shear-dependent integrin adhesion in platelets, leading to accelerated platelet thrombus growth. Conclusion: Dok-2 is a shear-specific negative regulator of blood clot formation. Significance: Dok-2 regulates biomechanical platelet adhesion, and targeting this molecule may provide new avenues to regulate thrombosis. ? 2014 by The American Society for Biochemistry and Molecular Biology, Inc.",
author = "Hughan, {Sascha Claire} and Spring, {Christopher Mitchell} and Schoenwaelder, {Simone Marianne} and Sturgeon, {Sharelle Anne} and Imala Alwis and Yu-Ping Yuan and McFadyen, {James David} and Erik Westein and Goddard, {Duncan Martin} and Akiko Ono and Yuji Yamanashi and Nesbitt, {Warwick Scott} and Shaun Jackson",
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language = "English",
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Hughan, SC, Spring, CM, Schoenwaelder, SM, Sturgeon, SA, Alwis, I, Yuan, Y-P, McFadyen, JD, Westein, E, Goddard, DM, Ono, A, Yamanashi, Y, Nesbitt, WS & Jackson, S 2014, 'Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrin aIIb{beta}3 in mice', Journal of Biological Chemistry, vol. 289, no. 8, pp. 5051 - 5060. https://doi.org/10.1074/jbc.M113.520148

Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrin aIIb{beta}3 in mice. / Hughan, Sascha Claire; Spring, Christopher Mitchell; Schoenwaelder, Simone Marianne; Sturgeon, Sharelle Anne; Alwis, Imala; Yuan, Yu-Ping; McFadyen, James David; Westein, Erik; Goddard, Duncan Martin; Ono, Akiko; Yamanashi, Yuji; Nesbitt, Warwick Scott; Jackson, Shaun.

In: Journal of Biological Chemistry, Vol. 289, No. 8, 2014, p. 5051 - 5060.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Hughan, Sascha Claire

AU - Spring, Christopher Mitchell

AU - Schoenwaelder, Simone Marianne

AU - Sturgeon, Sharelle Anne

AU - Alwis, Imala

AU - Yuan, Yu-Ping

AU - McFadyen, James David

AU - Westein, Erik

AU - Goddard, Duncan Martin

AU - Ono, Akiko

AU - Yamanashi, Yuji

AU - Nesbitt, Warwick Scott

AU - Jackson, Shaun

PY - 2014

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AB - Background: Dok proteins are negative regulators of immunoreceptor signaling and, potentially, integrin adhesion receptors. Results: Deficiency of Dok-2 results in enhanced shear-dependent integrin adhesion in platelets, leading to accelerated platelet thrombus growth. Conclusion: Dok-2 is a shear-specific negative regulator of blood clot formation. Significance: Dok-2 regulates biomechanical platelet adhesion, and targeting this molecule may provide new avenues to regulate thrombosis. ? 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

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