TY - JOUR
T1 - Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrin aIIb{beta}3 in mice
AU - Hughan, Sascha Claire
AU - Spring, Christopher Mitchell
AU - Schoenwaelder, Simone Marianne
AU - Sturgeon, Sharelle Anne
AU - Alwis, Imala
AU - Yuan, Yu-Ping
AU - McFadyen, James David
AU - Westein, Erik
AU - Goddard, Duncan Martin
AU - Ono, Akiko
AU - Yamanashi, Yuji
AU - Nesbitt, Warwick Scott
AU - Jackson, Shaun
PY - 2014
Y1 - 2014
N2 - Background: Dok proteins are negative regulators of immunoreceptor signaling and, potentially, integrin adhesion receptors. Results: Deficiency of Dok-2 results in enhanced shear-dependent integrin adhesion in platelets, leading to accelerated platelet thrombus growth. Conclusion: Dok-2 is a shear-specific negative regulator of blood clot formation. Significance: Dok-2 regulates biomechanical platelet adhesion, and targeting this molecule may provide new avenues to regulate thrombosis. ? 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
AB - Background: Dok proteins are negative regulators of immunoreceptor signaling and, potentially, integrin adhesion receptors. Results: Deficiency of Dok-2 results in enhanced shear-dependent integrin adhesion in platelets, leading to accelerated platelet thrombus growth. Conclusion: Dok-2 is a shear-specific negative regulator of blood clot formation. Significance: Dok-2 regulates biomechanical platelet adhesion, and targeting this molecule may provide new avenues to regulate thrombosis. ? 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
UR - http://www.jbc.org/content/289/8/5051.full.pdf
U2 - 10.1074/jbc.M113.520148
DO - 10.1074/jbc.M113.520148
M3 - Article
SN - 0021-9258
VL - 289
SP - 5051
EP - 5060
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 8
ER -