Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrin aIIb{beta}3 in mice

Sascha Claire Hughan, Christopher Mitchell Spring, Simone Marianne Schoenwaelder, Sharelle Anne Sturgeon, Imala Alwis, Yu-Ping Yuan, James David McFadyen, Erik Westein, Duncan Martin Goddard, Akiko Ono, Yuji Yamanashi, Warwick Scott Nesbitt, Shaun Jackson

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8 Citations (Scopus)

Abstract

Background: Dok proteins are negative regulators of immunoreceptor signaling and, potentially, integrin adhesion receptors. Results: Deficiency of Dok-2 results in enhanced shear-dependent integrin adhesion in platelets, leading to accelerated platelet thrombus growth. Conclusion: Dok-2 is a shear-specific negative regulator of blood clot formation. Significance: Dok-2 regulates biomechanical platelet adhesion, and targeting this molecule may provide new avenues to regulate thrombosis. ? 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
Original languageEnglish
Pages (from-to)5051 - 5060
Number of pages10
JournalThe Journal of Biological Chemistry
Volume289
Issue number8
DOIs
Publication statusPublished - 2014

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