TY - JOUR
T1 - Does the prognosis of colorectal cancer vary with tumor site?
AU - Jafarabadi, Mohamad Asghari
AU - Mohammadi, Seyede Momeneh
AU - Hajizadeh, Ebrahim
AU - Kazemnejad, Anoshirvan
AU - Fatemi, Seyed Reza
PY - 2011
Y1 - 2011
N2 - Aim: The aim of this study was to compare prognostic factors between colon and rectal cancers. Background: Prognosis of Colorectal Cancer (CRC) may depend on the anatomical site. Patients and methods: A total of 1219 patients with CRC diagnosis according to the pathology report of RCGLD cancer registry, from 1 January 2002 to 1 October 2007, were entered into the study. Demographic and clinicopathological factors were analyzed using survival analysis. Results: From age at diagnosis, colon cancer had significantly better survival than rectal cancer (Multivariate Hazard Ratio (MVHR)=0.24; 95% Confidence Interval (CI) =(0.074-0.77)). Other factors, including marital status (MVHR =1.78; 95% CI =(0.33-9.62)), body mass index (BMI) (MVHR =1.21 and 1.54; 95% CI =(.30-4.85) and (.44-5.4) respectively for < 18.5 and >30 BMI groups), pathologic stage (MVHR =.64; 95% CI =(.21-1.98)) and alcohol history (MVHR =4.86; 95% CI =(.67-35.14)) were not significantly different between the two patient group but suggested a possible effect upon prognosis. Overall survival in rectum was better than that of colon. Conclusion: Our findings support this hypothesis that prognosis of CRC varies with tumor site.
AB - Aim: The aim of this study was to compare prognostic factors between colon and rectal cancers. Background: Prognosis of Colorectal Cancer (CRC) may depend on the anatomical site. Patients and methods: A total of 1219 patients with CRC diagnosis according to the pathology report of RCGLD cancer registry, from 1 January 2002 to 1 October 2007, were entered into the study. Demographic and clinicopathological factors were analyzed using survival analysis. Results: From age at diagnosis, colon cancer had significantly better survival than rectal cancer (Multivariate Hazard Ratio (MVHR)=0.24; 95% Confidence Interval (CI) =(0.074-0.77)). Other factors, including marital status (MVHR =1.78; 95% CI =(0.33-9.62)), body mass index (BMI) (MVHR =1.21 and 1.54; 95% CI =(.30-4.85) and (.44-5.4) respectively for < 18.5 and >30 BMI groups), pathologic stage (MVHR =.64; 95% CI =(.21-1.98)) and alcohol history (MVHR =4.86; 95% CI =(.67-35.14)) were not significantly different between the two patient group but suggested a possible effect upon prognosis. Overall survival in rectum was better than that of colon. Conclusion: Our findings support this hypothesis that prognosis of CRC varies with tumor site.
KW - Colorectal cancer
KW - Prognostic factors
KW - Survival analysis
UR - http://www.scopus.com/inward/record.url?scp=80053404061&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:80053404061
SN - 2008-2258
VL - 4
SP - 199
EP - 209
JO - Gastroenterology and Hepatology from Bed to Bench
JF - Gastroenterology and Hepatology from Bed to Bench
IS - 4
ER -