Does single-strand DNA break repair capacity influence oocyte maintenance and quality?

Saranya Giridharan, Karla J. Hutt, Amy L. Winship

Research output: Contribution to journalComment / DebateOtherpeer-review

1 Citation (Scopus)

Abstract

Human genome-wide association studies and evidence from animal models link ovarian ageing to double-strand (ds)DNA break repair capacity. Is there a connection between single-strand (ss)DNA repair mechanisms and ovarian function? We hypothesize that endogenous cellular processes subject oocytes to ssDNA lesions, and thus, ssDNA repair capacity is fundamental to their survival and maintenance.

Original languageEnglish
Pages (from-to)V15-V18
Number of pages4
JournalReproduction
Volume164
Issue number6
DOIs
Publication statusPublished - 1 Dec 2022

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