Does serelaxin treatment alter passive mechanical wall properties in small resistance arteries?

Maria Jelinic, Nicola Kahlberg, Laura J. Parry, Marianne Tare

Research output: Contribution to journalReview ArticleOtherpeer-review

4 Citations (Scopus)

Abstract

The peptide hormone relaxin is recognized for its connective tissue remodeling actions in the reproductive tract during pregnancy and parturition, but it also has vascular remodeling actions independent of pregnancy. Recombinant human relaxin (serelaxin) treatment in male and non-pregnant female rodents enhances passive arterial compliance in the renal vasculature. This review focuses on serelaxin's actions on passive mechanical wall properties in small arteries and highlights the diversity of responses to serelaxin treatment in rodents. Different experimental approaches (duration of serelaxin treatment, rat strain, age) and animal models of disease (obesity, hypertension) will be considered. Most studies in young rodents demonstrate that serelaxin treatment fails to alter passive compliance in resistance-size arteries (mesenteric and femoral arteries and cerebral parenchymal arterioles), suggesting that serelaxin's beneficial effects are minimal in healthy animals. Short-term serelaxin treatment (5d) in aged, obese, and spontaneously hypertensive rats (SHRs) is largely without effect on passive mechanical wall properties. However, a longer duration of serelaxin treatment in SHRs (14d) enhances passive compliance in large muscular arteries as well as resistance-size arteries. In conclusion, serelaxin is capable of vascular remodeling. Its actions are vascular bed-dependent, more prominent in disease, and likely requires a longer duration of treatment to be effective.

Original languageEnglish
Pages (from-to)631-636
Number of pages6
JournalMicrocirculation
Volume23
Issue number8
DOIs
Publication statusPublished - Nov 2016

Keywords

  • arterial compliance
  • relaxin
  • RXFP1
  • vascular remodeling

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