Does Fluid Type and Amount Affect Kidney Function in Critical Illness?

Research output: Contribution to journalReview ArticleOtherpeer-review

Abstract

Acute kidney injury (AKI) is common, although commonly used clinical diagnostic markers are imperfect. Intravenous fluid administration remains a cornerstone of therapy worldwide, but there is minimal evidence of efficacy for the use of fluid bolus therapy outside of specific circumstances, and emerging evidence associates fluid accumulation with worse renal outcomes and even increased mortality among critically ill patients. Artificial colloid solutions have been associated with harm, and chloride-rich solutions may adversely affect renal function. Large trials to provide guidance regarding the optimal fluid choices to prevent or ameliorate AKI, and promote renal recovery, are urgently required.

Original languageEnglish
Pages (from-to)279-298
Number of pages20
JournalCritical Care Clinics
Volume34
Issue number2
DOIs
Publication statusPublished - 1 Apr 2018

Keywords

  • Acute kidney injury
  • Albumin
  • Balanced solution
  • Colloid
  • Crystalloid
  • Hydroxyethyl starch
  • Intravenous fluid therapy
  • Succinylated gelatin

Cite this

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title = "Does Fluid Type and Amount Affect Kidney Function in Critical Illness?",
abstract = "Acute kidney injury (AKI) is common, although commonly used clinical diagnostic markers are imperfect. Intravenous fluid administration remains a cornerstone of therapy worldwide, but there is minimal evidence of efficacy for the use of fluid bolus therapy outside of specific circumstances, and emerging evidence associates fluid accumulation with worse renal outcomes and even increased mortality among critically ill patients. Artificial colloid solutions have been associated with harm, and chloride-rich solutions may adversely affect renal function. Large trials to provide guidance regarding the optimal fluid choices to prevent or ameliorate AKI, and promote renal recovery, are urgently required.",
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Does Fluid Type and Amount Affect Kidney Function in Critical Illness? / Glassford, Neil J.; Bellomo, Rinaldo.

In: Critical Care Clinics, Vol. 34, No. 2, 01.04.2018, p. 279-298.

Research output: Contribution to journalReview ArticleOtherpeer-review

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