Does Combined Osteopenia/Osteoporosis and Sarcopenia Confer Greater Risk of Falls and Fracture Than Either Condition Alone in Older Men? The Concord Health and Ageing in Men Project

David Scott, Markus Seibel, Robert Cumming, Vasi Naganathan, Fiona Blyth, David G Le Couteur, David J Handelsman, Louise M Waite, Vasant Hirani

Research output: Contribution to journalArticleResearchpeer-review

Abstract

It is unclear whether older men with osteopenia/osteoporosis and sarcopenia (so-called osteosarcopenia) are at greater risk of falls and fractures than those with either condition alone.One thousand five hundred seventy-five community-dwelling men aged ≥70 years had appendicular lean mass, total hip and lumbar spine bone mineral density determined by dual-energy x-ray absorptiometry, and completed hand grip strength and gait speed tests. Osteopenia/osteoporosis was defined as a T-score at any site ≤−1.0 SD. Sarcopenia was defined using the European Working Group on Sarcopenia algorithm. Participants were contacted every 4 months for 6 ± 2 years to ascertain incident fractures (confirmed by radiographic reports) and for 2 years for incident falls.Prevalence of osteosarcopenia was 8\ while 34\% of participants had osteopenia/osteoporosis alone and 7\% had sarcopenia alone. Men with osteosarcopenia had significantly increased fall (incidence rate ratio: 1.41; 95\% confidence interval [CI]: 1.02 to 1.95) and fracture risk (hazard ratio: 1.87; 95\% CI: 1.07 to 3.26) compared with men with neither osteopenia/osteoporosis nor sarcopenia. There was no statistical interaction between osteopenia/osteoporosis and sarcopenia, and falls and fracture risk were not different for osteosarcopenia compared with either condition alone (all p \gt; .05).Community-dwelling older men with combined osteopenia/osteoporosis and sarcopenia do not have increased falls and fracture risk compared with those with either condition. Further research is required to clarify whether the term “osteosarcopenia” has any meaning above and beyond either term alone and therefore potential clinical utility for falls and fracture prediction.
Original languageEnglish
Pages (from-to)827-834
Number of pages8
JournalJournal of Gerontology Series A: Biological Sciences and Medical Sciences
Volume74
Issue number6
DOIs
Publication statusPublished - 16 May 2019

Cite this

Scott, David ; Seibel, Markus ; Cumming, Robert ; Naganathan, Vasi ; Blyth, Fiona ; Le Couteur, David G ; Handelsman, David J ; Waite, Louise M ; Hirani, Vasant. / Does Combined Osteopenia/Osteoporosis and Sarcopenia Confer Greater Risk of Falls and Fracture Than Either Condition Alone in Older Men? The Concord Health and Ageing in Men Project. In: Journal of Gerontology Series A: Biological Sciences and Medical Sciences. 2019 ; Vol. 74, No. 6. pp. 827-834.
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abstract = "It is unclear whether older men with osteopenia/osteoporosis and sarcopenia (so-called osteosarcopenia) are at greater risk of falls and fractures than those with either condition alone.One thousand five hundred seventy-five community-dwelling men aged ≥70 years had appendicular lean mass, total hip and lumbar spine bone mineral density determined by dual-energy x-ray absorptiometry, and completed hand grip strength and gait speed tests. Osteopenia/osteoporosis was defined as a T-score at any site ≤−1.0 SD. Sarcopenia was defined using the European Working Group on Sarcopenia algorithm. Participants were contacted every 4 months for 6 ± 2 years to ascertain incident fractures (confirmed by radiographic reports) and for 2 years for incident falls.Prevalence of osteosarcopenia was 8\ while 34\{\%} of participants had osteopenia/osteoporosis alone and 7\{\%} had sarcopenia alone. Men with osteosarcopenia had significantly increased fall (incidence rate ratio: 1.41; 95\{\%} confidence interval [CI]: 1.02 to 1.95) and fracture risk (hazard ratio: 1.87; 95\{\%} CI: 1.07 to 3.26) compared with men with neither osteopenia/osteoporosis nor sarcopenia. There was no statistical interaction between osteopenia/osteoporosis and sarcopenia, and falls and fracture risk were not different for osteosarcopenia compared with either condition alone (all p \gt; .05).Community-dwelling older men with combined osteopenia/osteoporosis and sarcopenia do not have increased falls and fracture risk compared with those with either condition. Further research is required to clarify whether the term “osteosarcopenia” has any meaning above and beyond either term alone and therefore potential clinical utility for falls and fracture prediction.",
author = "David Scott and Markus Seibel and Robert Cumming and Vasi Naganathan and Fiona Blyth and {Le Couteur}, {David G} and Handelsman, {David J} and Waite, {Louise M} and Vasant Hirani",
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Does Combined Osteopenia/Osteoporosis and Sarcopenia Confer Greater Risk of Falls and Fracture Than Either Condition Alone in Older Men? The Concord Health and Ageing in Men Project. / Scott, David; Seibel, Markus; Cumming, Robert; Naganathan, Vasi; Blyth, Fiona; Le Couteur, David G; Handelsman, David J; Waite, Louise M; Hirani, Vasant.

In: Journal of Gerontology Series A: Biological Sciences and Medical Sciences, Vol. 74, No. 6, 16.05.2019, p. 827-834.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Does Combined Osteopenia/Osteoporosis and Sarcopenia Confer Greater Risk of Falls and Fracture Than Either Condition Alone in Older Men? The Concord Health and Ageing in Men Project

AU - Scott, David

AU - Seibel, Markus

AU - Cumming, Robert

AU - Naganathan, Vasi

AU - Blyth, Fiona

AU - Le Couteur, David G

AU - Handelsman, David J

AU - Waite, Louise M

AU - Hirani, Vasant

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N2 - It is unclear whether older men with osteopenia/osteoporosis and sarcopenia (so-called osteosarcopenia) are at greater risk of falls and fractures than those with either condition alone.One thousand five hundred seventy-five community-dwelling men aged ≥70 years had appendicular lean mass, total hip and lumbar spine bone mineral density determined by dual-energy x-ray absorptiometry, and completed hand grip strength and gait speed tests. Osteopenia/osteoporosis was defined as a T-score at any site ≤−1.0 SD. Sarcopenia was defined using the European Working Group on Sarcopenia algorithm. Participants were contacted every 4 months for 6 ± 2 years to ascertain incident fractures (confirmed by radiographic reports) and for 2 years for incident falls.Prevalence of osteosarcopenia was 8\ while 34\% of participants had osteopenia/osteoporosis alone and 7\% had sarcopenia alone. Men with osteosarcopenia had significantly increased fall (incidence rate ratio: 1.41; 95\% confidence interval [CI]: 1.02 to 1.95) and fracture risk (hazard ratio: 1.87; 95\% CI: 1.07 to 3.26) compared with men with neither osteopenia/osteoporosis nor sarcopenia. There was no statistical interaction between osteopenia/osteoporosis and sarcopenia, and falls and fracture risk were not different for osteosarcopenia compared with either condition alone (all p \gt; .05).Community-dwelling older men with combined osteopenia/osteoporosis and sarcopenia do not have increased falls and fracture risk compared with those with either condition. Further research is required to clarify whether the term “osteosarcopenia” has any meaning above and beyond either term alone and therefore potential clinical utility for falls and fracture prediction.

AB - It is unclear whether older men with osteopenia/osteoporosis and sarcopenia (so-called osteosarcopenia) are at greater risk of falls and fractures than those with either condition alone.One thousand five hundred seventy-five community-dwelling men aged ≥70 years had appendicular lean mass, total hip and lumbar spine bone mineral density determined by dual-energy x-ray absorptiometry, and completed hand grip strength and gait speed tests. Osteopenia/osteoporosis was defined as a T-score at any site ≤−1.0 SD. Sarcopenia was defined using the European Working Group on Sarcopenia algorithm. Participants were contacted every 4 months for 6 ± 2 years to ascertain incident fractures (confirmed by radiographic reports) and for 2 years for incident falls.Prevalence of osteosarcopenia was 8\ while 34\% of participants had osteopenia/osteoporosis alone and 7\% had sarcopenia alone. Men with osteosarcopenia had significantly increased fall (incidence rate ratio: 1.41; 95\% confidence interval [CI]: 1.02 to 1.95) and fracture risk (hazard ratio: 1.87; 95\% CI: 1.07 to 3.26) compared with men with neither osteopenia/osteoporosis nor sarcopenia. There was no statistical interaction between osteopenia/osteoporosis and sarcopenia, and falls and fracture risk were not different for osteosarcopenia compared with either condition alone (all p \gt; .05).Community-dwelling older men with combined osteopenia/osteoporosis and sarcopenia do not have increased falls and fracture risk compared with those with either condition. Further research is required to clarify whether the term “osteosarcopenia” has any meaning above and beyond either term alone and therefore potential clinical utility for falls and fracture prediction.

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DO - 10.1093/gerona/gly162

M3 - Article

VL - 74

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EP - 834

JO - Journal of Gerontology Series A: Biological Sciences and Medical Sciences

JF - Journal of Gerontology Series A: Biological Sciences and Medical Sciences

SN - 1079-5006

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ER -