TY - JOUR
T1 - Does combination of Lactobacillus rhamnosus Heriz I and beta glucan improve quality of life in women with breast cancer receiving chemotherapy?
T2 - A randomized double-blind placebo-controlled clinical trial
AU - Monshikarimi, Alireza
AU - Ostadrahimi, Alireza
AU - Asghari Jafarabadi, Mohammad
AU - EivaziZiaei, Jamal
AU - Barzeghari, Abolfazl
AU - Esfahani, Ali
AU - Payahoo, Laleh
AU - Aamazadeh, Fatemeh
AU - Farrin, Nazila
N1 - Funding Information:
The authors acknowledge all the women who participated in this study. The present study was funded by Hematology Oncology Research Center of Tabriz University of Medical Sciences. The authors thank Quality of Life department in EORTC for authorizing the EORTC QLQ-C30 questionnaire use in this study. This article is from a data set of PhD thesis, registered in Tabriz University of Medical Sciences (No.d/31).
Funding Information:
The authors acknowledge all the women who participated in this study. The present study was funded by Hematology Oncology Research Center of Tabriz University of Medical Sciences. The authors thank Quality of Life department in EORTC for authorizing the EORTC QLQ-C30 questionnaire use in this study. This article is from a data set of PhD thesis, registered in Tabriz University of Medical Sciences (No.d/31). The authors have no conflict of interest.
Publisher Copyright:
© 2019, Emerald Publishing Limited.
PY - 2020/4/22
Y1 - 2020/4/22
N2 - Purpose: This paper aims to study the impact of combination Lactobacillus Rhamnosus Heriz I and Beta glucan on quality of life (QOL) in breast cancer (BC) patients receiving chemotherapy. Design/methodology/approach: In all, 30 women with BC were enrolled in this randomized double-blind placebo-controlled clinical trial. Intervention group received either daily one capsule of L. rhamnosus strain Heriz I (2 × 107 CFU) and two 10-mg capsules of soluble1–3,1–6,D-beta glucan and the placebo group receiving placebo, interval between two courses of chemotherapy. Health-related QOL was evaluated at baseline and end of the trial using the EORTC QOL Questionnaire version.3.0 (EORTC QLQ-C30). Findings: The results showed that combination of L. rhamnosus Heriz I and Beta glucan supplementation in BC patients during chemotherapy improved functional scales score from 37.3 ± 12.1 to 39.8 ± 6.8 and this increase in comparison with placebo was significant after adjusting baseline value (p = 0.015). Changes in symptoms scores were not significant after intervention (p = 0.05) but the decreased score (66.1 ± 12.9 to 60.6 ± 9.4) was considerable clinically. As well as, changes in global health status/QOL score in intervention group in comparison with the placebo group was not significant (p = 0.93). Originality/value: The findings suggest that combination of L. rhamnosus Heriz I and Beta glucan may be associated for improving functional scales and symptoms in patients with BC who underwent chemotherapy. To prove positive effect of supplements on other aspects of QOL, further studies are needed.
AB - Purpose: This paper aims to study the impact of combination Lactobacillus Rhamnosus Heriz I and Beta glucan on quality of life (QOL) in breast cancer (BC) patients receiving chemotherapy. Design/methodology/approach: In all, 30 women with BC were enrolled in this randomized double-blind placebo-controlled clinical trial. Intervention group received either daily one capsule of L. rhamnosus strain Heriz I (2 × 107 CFU) and two 10-mg capsules of soluble1–3,1–6,D-beta glucan and the placebo group receiving placebo, interval between two courses of chemotherapy. Health-related QOL was evaluated at baseline and end of the trial using the EORTC QOL Questionnaire version.3.0 (EORTC QLQ-C30). Findings: The results showed that combination of L. rhamnosus Heriz I and Beta glucan supplementation in BC patients during chemotherapy improved functional scales score from 37.3 ± 12.1 to 39.8 ± 6.8 and this increase in comparison with placebo was significant after adjusting baseline value (p = 0.015). Changes in symptoms scores were not significant after intervention (p = 0.05) but the decreased score (66.1 ± 12.9 to 60.6 ± 9.4) was considerable clinically. As well as, changes in global health status/QOL score in intervention group in comparison with the placebo group was not significant (p = 0.93). Originality/value: The findings suggest that combination of L. rhamnosus Heriz I and Beta glucan may be associated for improving functional scales and symptoms in patients with BC who underwent chemotherapy. To prove positive effect of supplements on other aspects of QOL, further studies are needed.
KW - Beta glucan
KW - Breast cancer
KW - Chemotherapy
KW - Lactobacillus rhamnosus Heriz I
KW - Quality of life
UR - https://www.scopus.com/pages/publications/85073969970
U2 - 10.1108/NFS-05-2019-0146
DO - 10.1108/NFS-05-2019-0146
M3 - Article
AN - SCOPUS:85073969970
SN - 0034-6659
VL - 50
SP - 569
EP - 578
JO - Nutrition & Food Science
JF - Nutrition & Food Science
IS - 3
ER -
SDG 3 Good Health and Well-being