Does clozapine treat antipsychotic-induced behavioural supersensitivity through glutamate modulation within the striatum?

Prashant Tibrewal, Pramod C. Nair, Karen J. Gregory, Christopher J. Langmead, Sherry Kit Wa Chan, Tarun Bastiampillai

Research output: Contribution to journalComment / DebateOtherpeer-review

2 Citations (Scopus)


Behavioural supersensitivity may be a result of increased glutamate sensitivity of D2-MSN and reduced sensitivity to dopamine. We propose that clozapine may address behavioural supersensitivity by modulating glutamate activity which may partially explain its unique effectiveness in the setting of treatment resistant schizophrenia.
Original languageEnglish
Pages (from-to)1839-1842
Number of pages4
JournalMolecular Psychiatry
Issue number5
Publication statusPublished - May 2023

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