Does clozapine treat antipsychotic-induced behavioural supersensitivity through glutamate modulation within the striatum?

Prashant Tibrewal, Pramod C. Nair, Karen J. Gregory, Christopher J. Langmead, Sherry Kit Wa Chan, Tarun Bastiampillai

Research output: Contribution to journal › Comment / Debate › Other › peer-review

5 Citations (Scopus)

Abstract

Behavioural supersensitivity may be a result of increased glutamate sensitivity of D2-MSN and reduced sensitivity to dopamine. We propose that clozapine may address behavioural supersensitivity by modulating glutamate activity which may partially explain its unique effectiveness in the setting of treatment resistant schizophrenia.
Original languageEnglish
Pages (from-to)1839-1842
Number of pages4
JournalMolecular Psychiatry
Volume28
Issue number5
DOIs
Publication statusPublished - May 2023

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  • ARC Industrial Transformation Training Centre for Cryo-Electron Microscopy of Membrane Proteins for Drug Discovery

    Sexton, P. (Primary Chief Investigator (PCI)), Rouiller, I. (Chief Investigator (CI)), Wootten, D. (Chief Investigator (CI)), van Oijen, A. (Chief Investigator (CI)), Parker, M. W. (Chief Investigator (CI)), Lucet, I. (Partner Investigator (PI)), Griffin, M. D. W. (Chief Investigator (CI)), Adams, D. J. (Chief Investigator (CI)), Czabotar, P. E. (Partner Investigator (PI)), Flocco, M. (Partner Investigator (PI)), Han, S. (Partner Investigator (PI)), Shepherd, R. (Partner Investigator (PI)), Ciferri, C. (Partner Investigator (PI)), Williams, P. A. (Partner Investigator (PI)), Brown, D. (Partner Investigator (PI)), Schreuder, H. (Partner Investigator (PI)), Reedtz-Runge, S. (Partner Investigator (PI)), Drinkwater, C. (Partner Investigator (PI)), Howard, B. L. (Partner Investigator (PI)), Betigeri, G. (Partner Investigator (PI)), Pryor, E. (Partner Investigator (PI)), How, J. (Project Manager) & Christopoulos, T. (Chief Investigator (CI))

    Boehringer Ingelheim (Germany), AstraZeneca (United Kingdom)

    23/03/21 → 23/03/27

    Project: Research

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