Does cerebellar non-invasive brain stimulation affect corticospinal excitability in healthy individuals? A systematic review of literature and meta-analysis

Shabnam Behrangrad, Maryam Zoghi, Dawson Kidgell, Shapour Jaberzadeh

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

Numerous studies have indicated that non-invasive brain stimulation (NIBS) of the cerebellum could modulate corticospinal excitability (CSE) in young healthy individuals. However, there is no systematic review and meta-analysis that clarifies the effects of cerebellar NIBS on CSE. The aim of this study was to provide a meta-analytic summary of the effects of cerebellar NIBS on CSE. Seven search engines were used to identify any trial evaluating CSE before and after one session of cerebellar NIBS in healthy individuals up to June 2018. Twenty-six studies investigating the corticospinal responses following cerebellar NIBS were included. Meta-analysis was used to pool the findings from included studies. Effects were expressed as mean differences (MD) and the standard deviation (SD). Risk of bias was assessed with the Cochrane tool. Meta-analysis found that paired associative stimulation (PAS) with 2 ms interval, a combination of PAS with 21.5 ms interval and anodal transcranial direct current stimulation, and repetitive transcranial magnetic stimulation with a frequency of < 5 Hz increase CSE (P PAS2 < 0.00001, P PAS21.5 +a-tDCS = 0.02, P rTMS = 0.04). However, continuous theta burst stimulation, a combination of PAS with 25 ms interval and anodal transcranial direct current stimulation, and PAS with a 6 ms interval decreased CSE (P PAS6 < 0.00001, P cTBS < 0.00001, P PAS25 +a-tDCS = 0.003). The results of this review show that cerebellar NIBS techniques are a promising tool for increasing CSE.

Original languageEnglish
Pages (from-to)128-139
Number of pages12
JournalNeuroscience Letters
Volume706
DOIs
Publication statusPublished - 27 Jul 2019

Keywords

  • cerebellum
  • corticospinal excitability
  • motor evoked potential
  • Non-invasive brain stimulation
  • transcranial direct current stimulation
  • Transcranial magnetic stimulation

Cite this

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title = "Does cerebellar non-invasive brain stimulation affect corticospinal excitability in healthy individuals? A systematic review of literature and meta-analysis",
abstract = "Numerous studies have indicated that non-invasive brain stimulation (NIBS) of the cerebellum could modulate corticospinal excitability (CSE) in young healthy individuals. However, there is no systematic review and meta-analysis that clarifies the effects of cerebellar NIBS on CSE. The aim of this study was to provide a meta-analytic summary of the effects of cerebellar NIBS on CSE. Seven search engines were used to identify any trial evaluating CSE before and after one session of cerebellar NIBS in healthy individuals up to June 2018. Twenty-six studies investigating the corticospinal responses following cerebellar NIBS were included. Meta-analysis was used to pool the findings from included studies. Effects were expressed as mean differences (MD) and the standard deviation (SD). Risk of bias was assessed with the Cochrane tool. Meta-analysis found that paired associative stimulation (PAS) with 2 ms interval, a combination of PAS with 21.5 ms interval and anodal transcranial direct current stimulation, and repetitive transcranial magnetic stimulation with a frequency of < 5 Hz increase CSE (P PAS2 < 0.00001, P PAS21.5 +a-tDCS = 0.02, P rTMS = 0.04). However, continuous theta burst stimulation, a combination of PAS with 25 ms interval and anodal transcranial direct current stimulation, and PAS with a 6 ms interval decreased CSE (P PAS6 < 0.00001, P cTBS < 0.00001, P PAS25 +a-tDCS = 0.003). The results of this review show that cerebellar NIBS techniques are a promising tool for increasing CSE.",
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Does cerebellar non-invasive brain stimulation affect corticospinal excitability in healthy individuals? A systematic review of literature and meta-analysis. / Behrangrad, Shabnam; Zoghi, Maryam; Kidgell, Dawson; Jaberzadeh, Shapour.

In: Neuroscience Letters, Vol. 706, 27.07.2019, p. 128-139.

Research output: Contribution to journalReview ArticleResearchpeer-review

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T1 - Does cerebellar non-invasive brain stimulation affect corticospinal excitability in healthy individuals? A systematic review of literature and meta-analysis

AU - Behrangrad, Shabnam

AU - Zoghi, Maryam

AU - Kidgell, Dawson

AU - Jaberzadeh, Shapour

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KW - motor evoked potential

KW - Non-invasive brain stimulation

KW - transcranial direct current stimulation

KW - Transcranial magnetic stimulation

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DO - 10.1016/j.neulet.2019.05.025

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EP - 139

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JF - Neuroscience Letters

SN - 0304-3940

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