Docking studies of curcumin and with various phosphodiesterase 4 subtypes

Yau Xin Yi; Anand Gaurav; Gabriel A. Akowuah

doi:10.2174/1570163815666181017091655

Docking studies of curcumin and with various phosphodiesterase 4 subtypes

Yau Xin Yi, Anand Gaurav, Gabriel A. Akowuah

Research output: Contribution to journal › Article › Research › peer-review

2 Citations (Scopus)

Abstract

Introduction: The primary aim of this study is to understand the binding of curcumin and its analogues to different PDE4 subtypes and identification of the role of PDE4 subtype inhibition in the anti-inflammatory property of curcumin. Docking analysis has been used to acquire the above mentioned structural information and this has been further used for designing of curcumin derivatives with better anti-inflammatory activity.

Original language	English
Pages (from-to)	248-260
Number of pages	13
Journal	Current Drug Discovery Technologies
Volume	17
Issue number	2
DOIs	https://doi.org/10.2174/1570163815666181017091655
Publication status	Published - 2020
Externally published	Yes

Keywords

Anti-inflammatory property
Binding affinity
Curcumin and analogues
Docking study
PDE4 subtype inhibition
PDE4B selectivity

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Cite this

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abstract = "Introduction: The primary aim of this study is to understand the binding of curcumin and its analogues to different PDE4 subtypes and identification of the role of PDE4 subtype inhibition in the anti-inflammatory property of curcumin. Docking analysis has been used to acquire the above mentioned structural information and this has been further used for designing of curcumin derivatives with better anti-inflammatory activity.",

keywords = "Anti-inflammatory property, Binding affinity, Curcumin and analogues, Docking study, PDE4 subtype inhibition, PDE4B selectivity",

author = "Yi, \{Yau Xin\} and Anand Gaurav and Akowuah, \{Gabriel A.\}",

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AU - Yi, Yau Xin

AU - Gaurav, Anand

AU - Akowuah, Gabriel A.

PY - 2020

Y1 - 2020

N2 - Introduction: The primary aim of this study is to understand the binding of curcumin and its analogues to different PDE4 subtypes and identification of the role of PDE4 subtype inhibition in the anti-inflammatory property of curcumin. Docking analysis has been used to acquire the above mentioned structural information and this has been further used for designing of curcumin derivatives with better anti-inflammatory activity.

AB - Introduction: The primary aim of this study is to understand the binding of curcumin and its analogues to different PDE4 subtypes and identification of the role of PDE4 subtype inhibition in the anti-inflammatory property of curcumin. Docking analysis has been used to acquire the above mentioned structural information and this has been further used for designing of curcumin derivatives with better anti-inflammatory activity.

KW - Anti-inflammatory property

KW - Binding affinity

KW - Curcumin and analogues

KW - Docking study

KW - PDE4 subtype inhibition

KW - PDE4B selectivity

UR - https://www.scopus.com/pages/publications/85086920832

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DO - 10.2174/1570163815666181017091655

M3 - Article

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AN - SCOPUS:85086920832

SN - 1570-1638

VL - 17

SP - 248

EP - 260

JO - Current Drug Discovery Technologies

JF - Current Drug Discovery Technologies

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ER -

Docking studies of curcumin and with various phosphodiesterase 4 subtypes

Abstract

Keywords

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