Abstract
Docking proteins comprise a distinct category of intracellular, noncatalytic signalling protein, that function downstream of a variety of receptor and receptor-associated tyrosine kinases and regulate diverse physiological and pathological processes. The growth factor receptor bound 2-associated binder/Daughter of Sevenless, insulin receptor substrate, fibroblast growth factor receptor substrate 2 and downstream of tyrosine kinases protein families fall into this category. This minireview focuses on the structure, function and regulation of these proteins.
Original language | English |
---|---|
Pages (from-to) | 4356 - 4369 |
Number of pages | 14 |
Journal | The FEBS Journal |
Volume | 277 |
Issue number | 21 |
DOIs | |
Publication status | Published - 2010 |
Externally published | Yes |