Do prostanoids or nitric oxide mediate sensitization of the von Bezold-Jarisch reflex by B-type natriuretic peptide?

Colleen Thomas, Atul Sharma, Robyn Woods

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Abstract

Cardiac natriuretic peptides act on cardiopulmonary chemoreceptor afferents to enhance the von Bezolda??Jarisch reflex (BJR).a??Activity of the natriuretic peptide particulate guanylyl cyclase receptor is essential for full expression of the BJR. Whether natriuretic peptides act directly on cardiac afferents or they require another intermediate factor(s) for their effects on the BJR is unknown. Endogenous candidates tested as possible intermediates in the present study were prostanoids and nitric oxide (NO), plausible endogenous chemical mediators of cardiac chemoreflex activity.
Original languageEnglish
Pages (from-to)410 - 415
Number of pages6
JournalClinical and Experimental Pharmacology and Physiology
Volume38
Issue number7
DOIs
Publication statusPublished - 2011

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