Do demographics and tumour-related factors affect nodal yield at neck dissection? A retrospective cohort study

R S Lim, L Evans, A P George, N De Alwis, P Stimpson, S Merriel, C E B Giddings, B Billah, J A Smith, A Safdar, E Sigston

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Abstract

Background: Nodal metastasis is an important prognostic factor in head and neck squamous cell carcinoma. This study aimed to determine the average nodal basin yield per level of neck dissection, and to investigate if age, gender, body mass index, tumour size, depth of tumour invasion and p16 status influence nodal yield. Method: A retrospective review of 185 patients with head and neck squamous cell carcinoma generated 240 neck dissection specimens. Results: The respective mean nodal yields for levels I, II, III, IV and V were 5.27, 9.43, 8.49, 7.43 and 9.02 in non-cutaneous squamous cell carcinoma patients, and 4.2, 7.57, 9.65, 4.33 and 12.29 in cutaneous squamous cell carcinoma patients. Multiple regression analysis revealed that p16-positive patients with mucosal squamous cell carcinoma yielded, on average, 2.4 more nodes than their p16-negative peers (p = 0.04, 95 per cent confidence interval = 0.116 to 4.693). This figure was 3.84 (p = 0.008, 95 per cent confidence interval = 1.070 to 6.605) for p16-positive patients with oral cavity squamous cell carcinoma. Conclusion: In mucosal squamous cell carcinoma, p16-positive status significantly influenced nodal yield, with the impact being more pronounced in oral cavity squamous cell carcinoma patients.

Original languageEnglish
Pages (from-to)S36-S40
Number of pages5
JournalJournal of Laryngology and Otology
Volume131
Issue numberS1
DOIs
Publication statusPublished - 1 Jan 2017

Keywords

  • Age Of Onset
  • Body Mass Index
  • Gender
  • Neck Dissection
  • P16 Protein, Human
  • Squamous Cell Carcinoma

Cite this

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title = "Do demographics and tumour-related factors affect nodal yield at neck dissection? A retrospective cohort study",
abstract = "Background: Nodal metastasis is an important prognostic factor in head and neck squamous cell carcinoma. This study aimed to determine the average nodal basin yield per level of neck dissection, and to investigate if age, gender, body mass index, tumour size, depth of tumour invasion and p16 status influence nodal yield. Method: A retrospective review of 185 patients with head and neck squamous cell carcinoma generated 240 neck dissection specimens. Results: The respective mean nodal yields for levels I, II, III, IV and V were 5.27, 9.43, 8.49, 7.43 and 9.02 in non-cutaneous squamous cell carcinoma patients, and 4.2, 7.57, 9.65, 4.33 and 12.29 in cutaneous squamous cell carcinoma patients. Multiple regression analysis revealed that p16-positive patients with mucosal squamous cell carcinoma yielded, on average, 2.4 more nodes than their p16-negative peers (p = 0.04, 95 per cent confidence interval = 0.116 to 4.693). This figure was 3.84 (p = 0.008, 95 per cent confidence interval = 1.070 to 6.605) for p16-positive patients with oral cavity squamous cell carcinoma. Conclusion: In mucosal squamous cell carcinoma, p16-positive status significantly influenced nodal yield, with the impact being more pronounced in oral cavity squamous cell carcinoma patients.",
keywords = "Age Of Onset, Body Mass Index, Gender, Neck Dissection, P16 Protein, Human, Squamous Cell Carcinoma",
author = "Lim, {R S} and L Evans and George, {A P} and {De Alwis}, N and P Stimpson and S Merriel and Giddings, {C E B} and B Billah and Smith, {J A} and A Safdar and E Sigston",
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Do demographics and tumour-related factors affect nodal yield at neck dissection? A retrospective cohort study. / Lim, R S; Evans, L; George, A P; De Alwis, N; Stimpson, P; Merriel, S; Giddings, C E B; Billah, B; Smith, J A; Safdar, A; Sigston, E.

In: Journal of Laryngology and Otology, Vol. 131, No. S1, 01.01.2017, p. S36-S40.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Do demographics and tumour-related factors affect nodal yield at neck dissection? A retrospective cohort study

AU - Lim, R S

AU - Evans, L

AU - George, A P

AU - De Alwis, N

AU - Stimpson, P

AU - Merriel, S

AU - Giddings, C E B

AU - Billah, B

AU - Smith, J A

AU - Safdar, A

AU - Sigston, E

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Background: Nodal metastasis is an important prognostic factor in head and neck squamous cell carcinoma. This study aimed to determine the average nodal basin yield per level of neck dissection, and to investigate if age, gender, body mass index, tumour size, depth of tumour invasion and p16 status influence nodal yield. Method: A retrospective review of 185 patients with head and neck squamous cell carcinoma generated 240 neck dissection specimens. Results: The respective mean nodal yields for levels I, II, III, IV and V were 5.27, 9.43, 8.49, 7.43 and 9.02 in non-cutaneous squamous cell carcinoma patients, and 4.2, 7.57, 9.65, 4.33 and 12.29 in cutaneous squamous cell carcinoma patients. Multiple regression analysis revealed that p16-positive patients with mucosal squamous cell carcinoma yielded, on average, 2.4 more nodes than their p16-negative peers (p = 0.04, 95 per cent confidence interval = 0.116 to 4.693). This figure was 3.84 (p = 0.008, 95 per cent confidence interval = 1.070 to 6.605) for p16-positive patients with oral cavity squamous cell carcinoma. Conclusion: In mucosal squamous cell carcinoma, p16-positive status significantly influenced nodal yield, with the impact being more pronounced in oral cavity squamous cell carcinoma patients.

AB - Background: Nodal metastasis is an important prognostic factor in head and neck squamous cell carcinoma. This study aimed to determine the average nodal basin yield per level of neck dissection, and to investigate if age, gender, body mass index, tumour size, depth of tumour invasion and p16 status influence nodal yield. Method: A retrospective review of 185 patients with head and neck squamous cell carcinoma generated 240 neck dissection specimens. Results: The respective mean nodal yields for levels I, II, III, IV and V were 5.27, 9.43, 8.49, 7.43 and 9.02 in non-cutaneous squamous cell carcinoma patients, and 4.2, 7.57, 9.65, 4.33 and 12.29 in cutaneous squamous cell carcinoma patients. Multiple regression analysis revealed that p16-positive patients with mucosal squamous cell carcinoma yielded, on average, 2.4 more nodes than their p16-negative peers (p = 0.04, 95 per cent confidence interval = 0.116 to 4.693). This figure was 3.84 (p = 0.008, 95 per cent confidence interval = 1.070 to 6.605) for p16-positive patients with oral cavity squamous cell carcinoma. Conclusion: In mucosal squamous cell carcinoma, p16-positive status significantly influenced nodal yield, with the impact being more pronounced in oral cavity squamous cell carcinoma patients.

KW - Age Of Onset

KW - Body Mass Index

KW - Gender

KW - Neck Dissection

KW - P16 Protein, Human

KW - Squamous Cell Carcinoma

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DO - 10.1017/S0022215116009208

M3 - Article

VL - 131

SP - S36-S40

JO - Journal of Laryngology and Otology

JF - Journal of Laryngology and Otology

SN - 0022-2151

IS - S1

ER -