Do cytosolic factors prevent promiscuity at the membrane surface?

Trevor Lithgow, Peter B. Høj, Nicholas J. Hoogenraad

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Abstract

From the point of view of a preprotein, escaping from the cytosol into a specific organelle must seem an arduous, almost impossible task. How is it that preproteins resist the temptation to fold prematurely, to avoid the multiple membrane surfaces in the cell, and manage instead to enter only the translocation apparatus of a single organelle?

Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalFEBS Letters
Volume329
Issue number1-2
DOIs
Publication statusPublished - 23 Aug 1993
Externally publishedYes

Keywords

  • Cytosolic factor
  • Heat-shock protein
  • Molecular chaperone
  • Organelle biogenesis
  • Protein import
  • Protein sorting

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