Do cytosolic factors prevent promiscuity at the membrane surface?

Trevor Lithgow; Peter B. Høj; Nicholas J. Hoogenraad

doi:10.1016/0014-5793(93)80179-X

Do cytosolic factors prevent promiscuity at the membrane surface?

Trevor Lithgow, Peter B. Høj, Nicholas J. Hoogenraad

Research output: Contribution to journal › Article › Research › peer-review

22 Citations (Scopus)

Abstract

From the point of view of a preprotein, escaping from the cytosol into a specific organelle must seem an arduous, almost impossible task. How is it that preproteins resist the temptation to fold prematurely, to avoid the multiple membrane surfaces in the cell, and manage instead to enter only the translocation apparatus of a single organelle?

Original language	English
Pages (from-to)	1-4
Number of pages	4
Journal	FEBS Letters
Volume	329
Issue number	1-2
DOIs	https://doi.org/10.1016/0014-5793(93)80179-X
Publication status	Published - 23 Aug 1993
Externally published	Yes

Keywords

Cytosolic factor
Heat-shock protein
Molecular chaperone
Organelle biogenesis
Protein import
Protein sorting

Access to Document

10.1016/0014-5793(93)80179-X

Cite this

@article{244acbfa66f54d2e91454cdd53b12121,

title = "Do cytosolic factors prevent promiscuity at the membrane surface?",

abstract = "From the point of view of a preprotein, escaping from the cytosol into a specific organelle must seem an arduous, almost impossible task. How is it that preproteins resist the temptation to fold prematurely, to avoid the multiple membrane surfaces in the cell, and manage instead to enter only the translocation apparatus of a single organelle?",

keywords = "Cytosolic factor, Heat-shock protein, Molecular chaperone, Organelle biogenesis, Protein import, Protein sorting",

author = "Trevor Lithgow and H{\o}j, {Peter B.} and Hoogenraad, {Nicholas J.}",

year = "1993",

month = aug,

day = "23",

doi = "10.1016/0014-5793(93)80179-X",

language = "English",

volume = "329",

pages = "1--4",

journal = "FEBS Letters",

issn = "0014-5793",