TY - JOUR
T1 - DNAM-1 expression marks an alternative program of NK cell maturation
AU - Martinet, Ludovic
AU - de Andrade, Lucas Ferrari
AU - Guillerey, Camille
AU - Lee, Jason S
AU - Liu, Jing
AU - Souza-Fonseca-Guimaraes, Fernando
AU - Hutchinson, Dana S
AU - Kolesnik, Tatiana B
AU - Nicholson, Sandra E
AU - Huntington, Nicholas D
AU - Smyth, Mark J
PY - 2015
Y1 - 2015
N2 - Natural killer (NK) cells comprise a heterogeneous population of cells important for pathogen defense and cancer surveillance. However, the functional significance of this diversity is not fully understood. Here, we demonstrate through transcriptional profiling and functional studies that the activating receptor DNAM-1 (CD226) identifies two distinct NK cell functional subsets: DNAM-1(+) and DNAM-1(-) NK cells. DNAM-1(+) NK cells produce high levels of inflammatory cytokines, have enhanced interleukin 15 signaling, and proliferate vigorously. By contrast, DNAM-1(-) NK cells that differentiate from DNAM-1(+) NK cells have greater expression of NK-cell-receptor-related genes and are higher producers of MIP1 chemokines. Collectively, our data reveal the existence of a functional program of NK cell maturation marked by DNAM-1 expression.
AB - Natural killer (NK) cells comprise a heterogeneous population of cells important for pathogen defense and cancer surveillance. However, the functional significance of this diversity is not fully understood. Here, we demonstrate through transcriptional profiling and functional studies that the activating receptor DNAM-1 (CD226) identifies two distinct NK cell functional subsets: DNAM-1(+) and DNAM-1(-) NK cells. DNAM-1(+) NK cells produce high levels of inflammatory cytokines, have enhanced interleukin 15 signaling, and proliferate vigorously. By contrast, DNAM-1(-) NK cells that differentiate from DNAM-1(+) NK cells have greater expression of NK-cell-receptor-related genes and are higher producers of MIP1 chemokines. Collectively, our data reveal the existence of a functional program of NK cell maturation marked by DNAM-1 expression.
UR - http://www.sciencedirect.com/science/article/pii/S2211124715002594
U2 - 10.1016/j.celrep.2015.03.006
DO - 10.1016/j.celrep.2015.03.006
M3 - Article
VL - 11
SP - 85
EP - 97
JO - Cell Reports
JF - Cell Reports
SN - 2211-1247
IS - 1
ER -
