DNA Methylation–Based Measures of Biological Aging

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Abstract

Aging is associated with profound changes in DNA methylation. Recent studies have used DNA methylation to build very accurate age predictors, also named “epigenetic clocks,” that deviate from chronological age by only a few years. The individual-specific deviation from chronological age—represented by the residual from a regression of predicted age on chronological age—has been interpreted as a biomarker of biological aging and referred to as “age acceleration” or “epigenetic aging.” Numerous studies have investigated such measures of biological aging based on DNA methylation and have found them to be associated with mortality, disease, and risk factors for disease. Although the biological significance of age acceleration measures is not yet fully characterized, they represent a promising tool for epidemiologists and clinicians to study health. Other attempts to characterize how age-associated methylation changes relate to health are likely to emerge in the near future.
Original languageEnglish
Title of host publicationEpigenetics in Human Disease
EditorsTrygve O. Tollefsbol
PublisherElsevier
Chapter3
Pages39-64
Number of pages26
Volume6
Edition2nd
ISBN (Print)9780128122150
DOIs
Publication statusPublished - 2018
Externally publishedYes

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