DNA methylation status correlates with adult β-cell regeneration capacity

Ishant Khurana, Keith Al-Hasani, Scott Maxwell, Harikrishnan K.N, Jun Okabe, Mark E. Cooper, Patrick Collombat, Assam El-Osta

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)


The role of DNA methylation in β-cell neogenesis is poorly understood. We report that during the process of induced cell reprogramming, methylation content of the Ngn3 and Sox11 genes are diminished. These findings emphasise DNA methylation is a barrier in β-cell regeneration in adulthood, a well described pathophysiological phenomenon of major significance in explaining β-cell deficiency in diabetes in the adult pancreas.

Original languageEnglish
Article number7
Number of pages5
Journalnpj Regenerative Medicine
Issue number1
Publication statusPublished - 12 Feb 2021

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