Projects per year
Abstract
The role of DNA methylation in β-cell neogenesis is poorly understood. We report that during the process of induced cell reprogramming, methylation content of the Ngn3 and Sox11 genes are diminished. These findings emphasise DNA methylation is a barrier in β-cell regeneration in adulthood, a well described pathophysiological phenomenon of major significance in explaining β-cell deficiency in diabetes in the adult pancreas.
Original language | English |
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Article number | 7 |
Number of pages | 5 |
Journal | npj Regenerative Medicine |
Volume | 6 |
Issue number | 1 |
DOIs | |
Publication status | Published - 12 Feb 2021 |
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Identifying the epigenomic fingerprint of coronary heart disease in Chinese adults with type 2 diabetes
El-Osta, S., Huang, Y., Chan, J. C. N., Thomas, M., Cooper, M. & Khurana, I.
1/01/16 → 31/12/20
Project: Research
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New models of gene regulation in diabetic complications
El-Osta, S. & Khurana, I.
1/01/19 → 28/04/23
Project: Research