DNA methylation changes in advanced sessile serrated adenomas that precede progression to dysplasia

Lochlan J. Fennell (Photographer)

Research output: Non-textual formDataset / DatabaseOther


The CpG island methylator phenotype is common in both BRAF mutant colorectal cancer and their precursors, the sessile serrated adenoma (SSA). SSAs acquire dysplasia immediate prior to progressing to invasive cancer. Here we examine the methylome of the remnant non-dysplastic portion of dysplastic sessile serrated adenomas to identify changes that occur immediately prior to the development of overt histological dysplasia.
Original languageEnglish
Media of outputOnline
Publication statusPublished - 11 Jul 2019
Externally publishedYes

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