DNA methylation changes in advanced sessile serrated adenomas that precede progression to dysplasia

Lochlan J. Fennell

DNA methylation changes in advanced sessile serrated adenomas that precede progression to dysplasia

Research output: Non-textual form › Dataset / Database › Other

Abstract

The CpG island methylator phenotype is common in both BRAF mutant colorectal cancer and their precursors, the sessile serrated adenoma (SSA). SSAs acquire dysplasia immediate prior to progressing to invasive cancer. Here we examine the methylome of the remnant non-dysplastic portion of dysplastic sessile serrated adenomas to identify changes that occur immediately prior to the development of overt histological dysplasia.

Original language	English
Media of output	Online
Publication status	Published - 11 Jul 2019
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

https://www.ebi.ac.uk/biostudies/arrayexpress/studies/E-MTAB-7854Licence: Unspecified

Cite this

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title = "DNA methylation changes in advanced sessile serrated adenomas that precede progression to dysplasia",

abstract = "The CpG island methylator phenotype is common in both BRAF mutant colorectal cancer and their precursors, the sessile serrated adenoma (SSA). SSAs acquire dysplasia immediate prior to progressing to invasive cancer. Here we examine the methylome of the remnant non-dysplastic portion of dysplastic sessile serrated adenomas to identify changes that occur immediately prior to the development of overt histological dysplasia.",

author = "Fennell, {Lochlan J.}",

note = "E-MTAB-7854",

year = "2019",

month = jul,

day = "11",

language = "English",

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TY - ADVS

T1 - DNA methylation changes in advanced sessile serrated adenomas that precede progression to dysplasia

A2 - Fennell, Lochlan J.

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PY - 2019/7/11

Y1 - 2019/7/11

N2 - The CpG island methylator phenotype is common in both BRAF mutant colorectal cancer and their precursors, the sessile serrated adenoma (SSA). SSAs acquire dysplasia immediate prior to progressing to invasive cancer. Here we examine the methylome of the remnant non-dysplastic portion of dysplastic sessile serrated adenomas to identify changes that occur immediately prior to the development of overt histological dysplasia.

AB - The CpG island methylator phenotype is common in both BRAF mutant colorectal cancer and their precursors, the sessile serrated adenoma (SSA). SSAs acquire dysplasia immediate prior to progressing to invasive cancer. Here we examine the methylome of the remnant non-dysplastic portion of dysplastic sessile serrated adenomas to identify changes that occur immediately prior to the development of overt histological dysplasia.

M3 - Dataset / Database

ER -