DNA methylation and miRNA expression profiling in childhood B-cell acute lymphoblastic leukemia

Zac Chatterton, Leah Morenos, Richard Saffery, Jeffrey Mark Craig, David Ashley, Nicholas C. Wong

Research output: Contribution to journalReview ArticleResearchpeer-review

9 Citations (Scopus)

Abstract

Acute lymphoblastic leukemia (ALL) is the most common cancer in children in the modern world. Recent efforts in characterizing the genetic contribution to this disease through uncovering gene mutations, deletions and structural variation by genome-scale methods have only accounted for a modest proportion of children with ALL. This suggests that either further genetic contributions to ALL have yet to be characterized or other factors, such as epigenetic aberrations are involved. A number of DNA methylation and miRNA profiling studies have investigated the role of both in childhood ALL. Here, we review these profiling efforts, summarize their major findings and speculate as to what the future may hold.

Original languageEnglish
Pages (from-to)697-708
Number of pages12
JournalEpigenomics
Volume2
Issue number5
DOIs
Publication statusPublished - Oct 2010
Externally publishedYes

Keywords

  • biomarker
  • childhood/pediatric acute lymphoblastic leukemia
  • DNA methylation
  • epigenetics
  • miRNA

Cite this