DNA damage detection and repair, and the involvement of epigenetic states

Sahar Bassal, Assam El-Osta

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

Chromatin is a highly dynamic structure that acts alternately as a substrate and a template in a number of critical biological processes. Modification of chromatin is pertinent and is responsible for a number of nuclear processes, including DNA repair, replication, transcription, and recombination. The purpose of this review is to discuss specific interactions between chromatin remodeling, DNA repair, and transcription. These areas are demonstrated to share commonality, particularly with a number of key molecules that appear to have roles in a number of pathways. The implications of pathway cross-over and communication form a seamless continuation of genomic integrity and stability.

Original languageEnglish
Pages (from-to)101-109
Number of pages9
JournalHuman Mutation
Volume25
Issue number2
DOIs
Publication statusPublished - 21 Feb 2005

Keywords

  • Chromatin and transcription
  • DNA repair
  • Epigenetics
  • Methylation
  • Pathway coordination

Cite this

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DNA damage detection and repair, and the involvement of epigenetic states. / Bassal, Sahar; El-Osta, Assam.

In: Human Mutation, Vol. 25, No. 2, 21.02.2005, p. 101-109.

Research output: Contribution to journalReview ArticleResearchpeer-review

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