DNA and PNA as templates for building nanoassemblies via electrostatic complexation with gold nanoparticles

A. Gourishankar, S. Shukla, R. Pasricha, M. Sastry, K. N. Ganesh

Research output: Contribution to journalConference articleResearchpeer-review

12 Citations (Scopus)

Abstract

Organisation of nanoparticles on structurally well-defined templates is a first step towards creating nanomachines. In this respect, nucleic acids are ideal structural templates and a variety of secondary structures realizable from DNA/RNA-e.g., duplexes, hairpins, triplexes, cruciforms, tetraplexes can be exploited to engineer nanoparticle organization at will. We have used oligonucleotides and their analogues such as phosphorothioates and peptide nucleic acids to electrostatically encapsulate cationic-capped gold nanoparticles. This article describes synthesis and characterization of DNA/PNA-gold nanoparticle composites using TEM and UV-Tm techniques. These types of assemblies may have potential for creating nanowires and lithographic circuits.

Original languageEnglish
Pages (from-to)102-107
Number of pages6
JournalCurrent Applied Physics
Volume5
Issue number2
DOIs
Publication statusPublished - Feb 2005
Externally publishedYes
EventIndo-Japan Workshop on Advanced Molecular Electronics 2003 - Kitakyushu, Japan
Duration: 11 Dec 200312 Dec 2003

Keywords

  • DNA
  • DNA-gold nanoparticle interactions
  • Nanoassemblies
  • PNA

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